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Spectrophotometer for exploratory photoacoustic spectroscopy and molecular theragnostics

用于探索性光声光谱和分子治疗学的分光光度计

基本信息

批准号：
423345-2012
负责人：
Kolios, Michael
金额：
$ 6.57万
依托单位：
Ryerson University
依托单位国家：
加拿大
项目类别：
Research Tools and Instruments - Category 1 (<$150,000)
财政年份：
2011
资助国家：
加拿大
起止时间：
2011-01-01 至 2012-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=495921
关键词：
Spectrophotometer exploratory photoacoustic spectroscopy molecular

项目摘要

New methods are being developed to optically characterize biomaterials, tissues and tissue engineered modules. These methods include more conventional methods that rely on optical scattering and absorption such as near infrared imaging, and novel methods that include photoacoustic imaging. Moreover, small nanoparticles are being developed as contrast agents that would be used with the methods mentioned above to detect tumors early and to then treat them. The biomedical optics group at Ryerson University added two new faculty members this year that heavily rely on knowing the optical properties of the materials examined. In this grant, a high-end spectrophotometer is requested to achieve the measurement of the optical properties of biomaterials and tissue engineered modules. The instrument has sufficient sensitivity to detect light from materials that either greatly reduce the light intensity or do not change it at all, but also more importantly would be able to make the measurement for many different wavelengths of light. These attributes will greatly expand the range of experimental conditions that can be used optically characterize the biomaterials and tissue engineered constructs. Therefore, it is anticipated that the instrument will help many graduate students and highly qualified personnel in making the measurements required to understand the optical properties of the biomaterials being used.

正在开发新的方法来光学表征生物材料，组织和组织工程模块。这些方法包括依赖于光学散射和吸收的更传统的方法，例如近红外成像，以及包括光声成像的新方法。此外，正在开发小纳米颗粒作为造影剂，将与上述方法一起使用，以早期检测肿瘤，然后治疗它们。瑞尔森大学的生物医学光学小组今年增加了两名新的教员，他们在很大程度上依赖于对所研究材料的光学特性的了解。本研究拟利用一种高端分光光度计来实现生物材料和组织工程模块的光学特性测量。该仪器具有足够的灵敏度来检测来自材料的光，这些材料要么大大降低光强度，要么根本不改变光强度，但更重要的是，它能够测量许多不同波长的光。这些属性将极大地扩展可用于光学表征生物材料和组织工程构造的实验条件的范围。因此，预计该仪器将帮助许多研究生和高素质的人员进行所需的测量，以了解所使用的生物材料的光学特性。