Using the zebrafish as a pre-clinical animal tumour model for drug discovery and the evaluation of anti-leukemia agents

使用斑马鱼作为临床前动物肿瘤模型用于药物发现和抗白血病药物的评估

• 批准号: 249347
• 负责人: Dellaire Graham P
• 金额: $ 29.14万
• 依托单位: Dalhousie University (Nova Scotia)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-10-01 至 2014-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=249347&lang=en
• 关键词: Acute T-Lymphoblastic Leukemia; Akt And P13 Kinase Inhibitors; Animal Tumour Models; In Vivo Imaging; Light Microscopy; Mice; Personalized Therapy; Pre-Clinical Drug Testing; Zebrafish

"T-cell acute lymphoblastic leukemia (T-ALL) is a high risk subtype of the most common leukemia affecting children. Although intensive chemotherapy treatments have improved survival in this disease, a significant number of patients do not respond to thera

“T细胞急性淋巴细胞白血病（T-ALL）是影响儿童的最常见白血病的高风险亚型。尽管强化化疗治疗提高了该病的生存率，但仍有相当数量的患者对化疗无反应。