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Characterization of HR-Killer1 and identification of small molecules for cancer therapy and enhanced gene editing using CRISPR/Cas9-based DNA repair strategies

Characterization of HR-Killer1 and identification of small molecules for cancer therapy and enhanced gene editing using CRISPR/Cas9-based DNA repair strategies
HR-Killer1 的表征和癌症治疗小分子的鉴定以及使用基于 CRISPR/Cas9 的 DNA 修复策略增强基因编辑
批准号:
370240
负责人:
Dellaire Graham P
金额:
$77.47万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-09-01 至 2022-09-01

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中文摘要
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英文摘要
Inherited diseases arise from mutations in our genes, and similarly genetic mutations underlie the development of a variety of cancers. These mutations arise from DNA damage that is repaired incorrectly in our cells, and ironically radiation or drugs that
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Determining how PRP4K insufficiency impacts cancer signaling and therapy responses
  • 批准号:
    488837
  • 项目类别:
    Operating Grants
  • 资助金额:
    $85.82万
  • 财政年份:
    2023
  • 负责人:
    Dellaire Graham P
  • 依托单位:
Characterizing the evolutionarily conserved functions of the pre-mRNA processing factor 4 kinase in cellular stress
  • 批准号:
    477289
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    Dellaire Graham P
  • 依托单位:
1st Canadian Environmental Exposures in Cancer (CE2C) Network Meeting
  • 批准号:
    391953
  • 项目类别:
    Miscellaneous Programs
  • 资助金额:
    $0.73万
  • 财政年份:
    2018
  • 负责人:
    Dellaire Graham P
  • 依托单位:
Using the zebrafish as a pre-clinical animal tumour model for drug discovery and the evaluation of anti-leukemia agents
  • 批准号:
    249347
  • 项目类别:
    Operating Grants
  • 资助金额:
    $29.14万
  • 财政年份:
    2011
  • 负责人:
    Dellaire Graham P
  • 依托单位:
海外基金