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The promyelocytic leukemia protein and nuclear domain function in DNA damage signalling and tumour suppression

The promyelocytic leukemia protein and nuclear domain function in DNA damage signalling and tumour suppression
早幼粒细胞白血病蛋白和核结构域在 DNA 损伤信号传导和肿瘤抑制中的作用
批准号:
225545
负责人:
Dellaire Graham P
金额:
$55.15万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-03-01 至 2016-03-01

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中文摘要
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英文摘要
Cancer arises when cells accumulate genetic changes (mutations) that result from damage to our DNA. These mutations alter the normal regulation of cell growth and division, allowing cancer to develop. A cell normally prevents these mutations by efficient
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Determining how PRP4K insufficiency impacts cancer signaling and therapy responses
  • 批准号:
    488837
  • 项目类别:
    Operating Grants
  • 资助金额:
    $85.82万
  • 财政年份:
    2023
  • 负责人:
    Dellaire Graham P
  • 依托单位:
Characterizing the evolutionarily conserved functions of the pre-mRNA processing factor 4 kinase in cellular stress
  • 批准号:
    477289
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    Dellaire Graham P
  • 依托单位:
1st Canadian Environmental Exposures in Cancer (CE2C) Network Meeting
  • 批准号:
    391953
  • 项目类别:
    Miscellaneous Programs
  • 资助金额:
    $0.73万
  • 财政年份:
    2018
  • 负责人:
    Dellaire Graham P
  • 依托单位:
Characterization of HR-Killer1 and identification of small molecules for cancer therapy and enhanced gene editing using CRISPR/Cas9-based DNA repair strategies
  • 批准号:
    370240
  • 项目类别:
    Operating Grants
  • 资助金额:
    $77.47万
  • 财政年份:
    2017
  • 负责人:
    Dellaire Graham P
  • 依托单位:
海外基金