Sleep to remember: sleep-dependent learning and memory in children and adolescents

睡眠记忆：儿童和青少年依赖睡眠的学习和记忆

• 批准号: 341480-2009
• 负责人: Gruber, Reut
• 金额: $ 1.97万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=497209
• 关键词: Sleep; remember; sleep; dependent; learning

While sleep-dependent memory consolidation has been shown in numerous species, we do not yet understand the role of sleep in learning and memory in children and adolescents. Our long-term goal is to understand the interplay between the regulation of sleep and cognitive development. The objective of this application is to characterize the interplay between sleep regulation and the systems that regulate learning and memory in children and adolescents. The central hypothesis is that sleep is critical for learning and memory in children and adolescents. Our rationale for this study is that successful completion of the proposed research will contribute important insight into the underpinning of learning and memory in children and adolescents. Our contribution is expected to be significant because it is expected to advance our mechanistic understanding of fundamental processes that are critical in the developing brain. We plan to test our central hypothesis and accomplish our objectives by pursuing the following specific aims: 1) Characterize the Interplay Between Sleep and Learning/Memory in Children and Adolescents; 2) Determine the Relevance of Clock Genes to Individual Differences in the Impact of Sleep on Learning and Memory. This study has several strengths: 1) It is based on an innovative experimental approach; 2) It uses advanced objective methodology that overcomes previous methodological challenges in the field; 3) This will be the first study to examine the role of sleep in memory in adolescents; 4) This will be the first examination of the genetic mechanisms involved in these processes; and, 5) This will be the first study to examine the impact of sleep on memory of emotional vs. neutral information in youth. Our results will have an important positive impact, because they are expected to facilitate the understanding of the interplay among sleep, learning-memory in children and adolescents, while also offering unique multidisciplinary training to students at all levels. This will significantly advance the field of developmental neuroscience.

虽然睡眠依赖的记忆巩固已经在许多物种中被证明，但我们还不了解睡眠在儿童和青少年学习和记忆中的作用。我们的长期目标是了解睡眠调节和认知发展之间的相互作用。本申请的目的是表征睡眠调节与调节儿童和青少年学习和记忆的系统之间的相互作用。核心假设是睡眠对儿童和青少年的学习和记忆至关重要。我们进行这项研究的理由是，成功完成拟议的研究将有助于深入了解儿童和青少年学习和记忆的基础。我们的贡献预计将是显著的，因为它有望促进我们对发育中大脑关键的基本过程的机械理解。我们计划通过追求以下具体目标来测试我们的中心假设并实现我们的目标：1）描述儿童和青少年睡眠与学习/记忆之间的相互作用; 2）确定生物钟基因与睡眠对学习和记忆影响的个体差异的相关性。这项研究有几个优点：1）它是基于创新的实验方法; 2）它使用先进的客观方法，克服了以前在该领域的方法学挑战; 3）这将是第一个研究睡眠在青少年记忆中的作用; 4）这将是第一次检查参与这些过程的遗传机制; 5）这将是第一个研究睡眠对年轻人情感与中性信息记忆的影响的研究。我们的研究结果将产生重要的积极影响，因为它们有望促进对儿童和青少年睡眠，学习记忆之间相互作用的理解，同时还为各级学生提供独特的多学科培训。这将极大地推动发展神经科学领域的发展。