Dynamic targeting of protein phosphatase 1 (PP1) activity in vivo

体内蛋白磷酸酶 1 (PP1) 活性的动态靶向

• 批准号: 372370-2009
• 负责人: TrinkleMulcahy, Laura
• 金额: $ 2.33万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=498101
• 关键词: Dynamic; targeting; protein; phosphatase; PP1

Human cells express thousands of proteins, which make up their structure and carry out all of their regulatory functions. The activities of these proteins are coordinated by various mechanisms, including the reversible addition of a phosphate group to one of the amino acid building blocks of which they're composed. Over one-third of all cellular proteins are believed to be controlled in this way, and their so-called "phospho-states" are mediated by the competing activities of enzymes termed protein kinases (add phosphates) and protein phosphatases (remove phosphates). Phosphorylation events are found in nearly all signaling pathways within the cell, and thus it is critical to understand the enzymes that control them.

人类细胞表达数千种蛋白质，这些蛋白质构成了它们的结构并执行所有的调节功能。 这些蛋白质的活性通过各种机制来协调，包括将磷酸基团可逆地添加到组成它们的氨基酸结构单元之一上。 超过三分之一的细胞蛋白质被认为是以这种方式控制的，它们所谓的“磷酸状态”是由称为蛋白激酶（添加磷酸盐）和蛋白磷酸酶（去除磷酸盐）的酶的竞争活性介导的。 磷酸化事件在细胞内几乎所有的信号通路中都有发现，因此了解控制它们的酶是至关重要的。