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Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function

Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function
对核仁结构和功能调节的生物化学、蛋白质组学和微观见解
批准号:
RGPIN-2015-06674
负责人:
TrinkleMulcahy, Laura
金额:
$2.48万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-01-01 至 2016-12-31

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中文摘要
翻译
哺乳动物核核是一种非膜结合的核细胞器,在核糖体DNA串联重复序列周围形成,并以其在核糖体生物发生协调中的重要作用而闻名,核糖体为细胞提供蛋白质合成所需的核糖体复合物。这种结构是动态的,在哺乳动物细胞的每个细胞周期中都有分解和重组,并在各种细胞应力的作用下重组其内部结构。
英文摘要
The mammalian nucleolus is a non membrane-bound nuclear organelle that forms around tandem repeats of ribosomal DNA and is best known for its essential role in the coordination of ribosome biogenesis, which supplies the cell with the ribosome complexes required for protein synthesis. This structure is dynamic, disassembling and reassembling throughout each cell cycle in mammalian cells and reorganizing its internal structure in response to various cellular stresses.
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Temporal resolution of phosphorylation-mediated signalling events in DNA Damage Repair
  • 批准号:
    RGPIN-2020-06612
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.62万
  • 财政年份:
    2022
  • 负责人:
    TrinkleMulcahy, Laura
  • 依托单位:
Temporal resolution of phosphorylation-mediated signalling events in DNA Damage Repair
  • 批准号:
    RGPIN-2020-06612
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.62万
  • 财政年份:
    2021
  • 负责人:
    TrinkleMulcahy, Laura
  • 依托单位:
Temporal resolution of phosphorylation-mediated signalling events in DNA Damage Repair
  • 批准号:
    RGPIN-2020-06612
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.62万
  • 财政年份:
    2020
  • 负责人:
    TrinkleMulcahy, Laura
  • 依托单位:
Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function
  • 批准号:
    RGPIN-2015-06674
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.48万
  • 财政年份:
    2019
  • 负责人:
    TrinkleMulcahy, Laura
  • 依托单位:
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