Nerve-mediated control of the skeletal muscle fiber phenotype

骨骼肌纤维表型的神经介导控制

• 批准号: 46522-2009
• 负责人: Michel, Robin
• 金额: $ 2.19万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=504123
• 关键词: Nerve; mediated; control; skeletal; muscle

When nerves drive their muscle partners and make them work in a way that would prompt them to grow and become more energy efficient, calcium waves or oscillations are triggered in muscle cells that serve as a sort of molecular code. Calcineurin is an enzyme found in muscle cells that acts as a sensor for detection of these calcium waves or changing levels. We were the first to demonstrate novel features of this exciting molecule and its key role at the nexus of signaling pathways leading to skeletal muscle adaptations and growth. Calcineurin and its molecular partners are brought into play to decipher the calcium code and enact mechanisms that will eventually lead to the activation of genes necessary for muscle growth and muscle efficiency. As such, we liken the signals responsible for muscle growth to a perfect symphony with calcineurin acting as first violinist, taking the lead, but playing in concert with all other instruments in the orchestra.

当神经驱动他们的肌肉伙伴，并让他们以一种促使他们成长并变得更有能量效率的方式工作时，肌肉细胞中的钙波动或振荡就会被触发，作为一种分子密码。钙调神经磷酸酶是在肌肉细胞中发现的一种酶，它作为传感器来检测这些钙波或变化的水平。我们第一个展示了这种令人兴奋的分子的新特征及其在导致骨骼肌适应和生长的信号通路联系中的关键作用。钙调神经磷酸酶和它的分子伴侣被用来破译钙密码并制定最终导致肌肉生长和肌肉效率所需基因激活的机制。因此，我们将负责肌肉生长的信号比作一首完美的交响乐，钙调神经磷酸酶担任第一小提琴手，发挥带头作用，但与管弦乐队中的所有其他乐器协同演奏。