Nerve-mediated control of the skeletal muscle fiber phenotype

当神经驱动它们的肌肉伙伴，并使它们以一种促使它们生长并变得更节能的方式工作时，钙波或振荡就会在肌肉细胞中被触发，作为一种分子密码。钙调磷酸酶是一种在肌肉细胞中发现的酶，它作为传感器检测这些钙波或钙水平的变化。我们是第一个证明这种令人兴奋的分子的新特征及其在导致骨骼肌适应和生长的信号通路中的关键作用的人。钙调磷酸酶和它的分子伙伴被用来破译钙密码，并制定机制，最终导致激活肌肉生长和肌肉效率所需的基因。因此，我们把负责肌肉生长的信号比作一首完美的交响乐，钙调神经磷酸酶作为第一小提琴手，带头，但与管弦乐队中的所有其他乐器一起演奏。

When nerves drive their muscle partners and make them work in a way that would prompt them to grow and become more energy efficient, calcium waves or oscillations are triggered in muscle cells that serve as a sort of molecular code. Calcineurin is an enzyme found in muscle cells that acts as a sensor for detection of these calcium waves or changing levels. We were the first to demonstrate novel features of this exciting molecule and its key role at the nexus of signaling pathways leading to skeletal muscle adaptations and growth. Calcineurin and its molecular partners are brought into play to decipher the calcium code and enact mechanisms that will eventually lead to the activation of genes necessary for muscle growth and muscle efficiency. As such, we liken the signals responsible for muscle growth to a perfect symphony with calcineurin acting as first violinist, taking the lead, but playing in concert with all other instruments in the orchestra.