Development of droplet-based microfluidic technology for drug discovery, drug delivery and biomedical diagnosis applications

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We have been developing microfluidic chip technology for chemical and biomedical assays. The major tools used for our development include numerical simulation for chip design and optimization, microfabrication using softlithography and conventional photolithography technology, and characterization using both UV- and fluorescence-based visualization techniques. Examples of recently developed microdevices include particle sorting and counting chips, cell culture chips, protein chips and microgrippers. The major applications target three areas which are: i) chemical detection for water and food safety control; ii) biomarker-based disease diagnosis and iii) cell-based analysis for drug discovery and delivery. The proposed research program will support the third direction: cell-based analysis for drug discovery, drug delivery and biomedical diagnosis.