权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Biophysical basis of single cell force spectroscopy

单细胞力谱的生物物理基础

基本信息

批准号：
355350-2010
负责人：
Shi, Yan
金额：
$ 4.81万
依托单位：
University of Calgary
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Group
财政年份：
2012
资助国家：
加拿大
起止时间：
2012-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=505662
关键词：
Biophysical basis single cell force

项目摘要

Biological processes such as embryogenesis, organ development, cellular communication, immune response, and a large spectrum of host-pathogen interactions are at some level defined by adhesion forces between interacting entities, an area foreign to all but few selected biophysicists. Such adhesive interaction should also play a crucial role in medical interventions, including delivery of particulate drug regimens and prosthetic implant. Another example is inhaled particles. To have adverse health effect, they need to adhere to the air-lung interface. A method to explore this integral aspect of biology will revolutionize modern biological research and medical intervention.

生物过程，如胚胎发生，器官发育，细胞通讯，免疫反应，和大量的宿主-病原体相互作用在一定程度上由相互作用实体之间的粘附力定义，这是一个对所有但很少有选择的生物药理学家都陌生的领域。这种粘合剂相互作用也应该在医疗干预中发挥关键作用，包括颗粒药物方案和假体植入物的递送。另一个例子是吸入颗粒物。要对健康产生不良影响，它们需要粘附在气肺界面上。探索生物学这一不可或缺的方面的方法将彻底改变现代生物学研究和医疗干预。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

数据更新时间：{{ journalArticles.updateTime }}

DOI：
{{ item.doi }}
发表时间：
{{ item.publish_year }}
期刊：
{{ item.journal_name }}
影响因子：
{{ item.factor }}
作者：
{{ item.authors }}
通讯作者：
{{ item.author }}

数据更新时间：{{ journalArticles.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ monograph.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ sciAawards.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ conferencePapers.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ patent.updateTime }}

Shi, Yan其他文献

Comprehensive genomic characterization of squamous cell lung cancers.

DOI：
10.1038/nature11404
发表时间：
2012-09-27
期刊：
NATURE
影响因子：
64.8
作者：
Hammerman, Peter S.;Lawrence, Michael S.;Voet, Douglas;Jing, Rui;Cibulskis, Kristian;Sivachenko, Andrey;Stojanov, Petar;McKenna, Aaron;Lander, Eric S.;Gabriel, Stacey;Getz, Gad;Sougnez, Carrie;Imielinski, Marcin;Helman, Elena;Hernandez, Bryan;Pho, Nam H.;Meyerson, Matthew;Chu, Andy;Chun, Hye-Jung E.;Mungall, Andrew J.;Pleasance, Erin;Robertson, A. Gordon;Sipahimalani, Payal;Stoll, Dominik;Balasundaram, Miruna;Birol, Inanc;Butterfield, Yaron S. N.;Chuah, Eric;Coope, Robin J. N.;Corbett, Richard;Dhalla, Noreen;Guin, Ranabir;Hirst, Anhe Carrie;Hirst, Martin;Holt, Robert A.;Lee, Darlene;Li, Haiyan I.;Mayo, Michael;Moore, Richard A.;Mungall, Karen;Nip, Ka Ming;Olshen, Adam;Schein, Jacqueline E.;Slobodan, Jared R.;Tam, Angela;Thiessen, Nina;Varhol, Richard;Zeng, Thomas;Zhao, Yongjun;Jones, Steven J. M.;Marra, Marco A.;Saksena, Gordon;Cherniack, Andrew D.;Schumacher, Stephen E.;Tabak, Barbara;Carter, Scott L.;Pho, Nam H.;Nguyen, Huy;Onofrio, Robert C.;Crenshaw, Andrew;Ardlie, Kristin;Beroukhim, Rameen;Winckler, Wendy;Hammerman, Peter S.;Getz, Gad;Meyerson, Matthew;Protopopov, Alexei;Zhang, Jianhua;Hadjipanayis, Angela;Lee, Semin;Xi, Ruibin;Yang, Lixing;Ren, Xiaojia;Zhang, Hailei;Shukla, Sachet;Chen, Peng-Chieh;Haseley, Psalm;Lee, Eunjung;Chin, Lynda;Park, Peter J.;Kucherlapati, Raju;Socci, Nicholas D.;Liang, Yupu;Schultz, Nikolaus;Borsu, Laetitia;Lash, Alex E.;Viale, Agnes;Sander, Chris;Ladanyi, Marc;Auman, J. Todd;Hoadley, Katherine A.;Wilkerson, Matthew D.;Shi, Yan;Liquori, Christina;Meng, Shaowu;Li, Ling;Turman, Yidi J.;Topal, Michael D.;Tan, Donghui;Waring, Scot;Buda, Elizabeth;Walsh, Jesse;Jones, Corbin D.;Mieczkowski, Piotr A.;Singh, Darshan;Wu, Junyuan;Gulabani, Anisha;Dolina, Peter;Bodenheimer, Tom;Hoyle, Alan P.;Simons, Janae V.;Soloway, Matthew G.;Mose, Lisle E.;Jefferys, Stuart R.;Balu, Saianand;O'Connor, Brian D.;Prins, Jan F.;Liu, Jinze;Chiang, Derek Y.;Hayes, D. Neil;Perou, Charles M.;Cope, Leslie;Danilova, Ludmila;Weisenberger, Daniel J.;Maglinte, Dennis T.;Pan, Fei;Van den Berg, David J.;Triche, Timothy;Herman, James G.;Baylin, Stephen B.;Laird, Peter W.;Getz, Gad;Noble, Michael;Voet, Doug;Saksena, Gordon;Gehlenborg, Nils;DiCara, Daniel;Zhang, Jinhua;Zhang, Hailei;Wu, Chang-Jiun;Liu, Spring Yingchun;Lawrence, Michael S.;Zou, Lihua;Sivachenko, Andrey;Lin, Pei;Stojanov, Petar;Jing, Rui;Cho, Juok;Nazaire, Marc-Danie;Robinson, Jim;Thorvaldsdottir, Helga;Mesirov, Jill;Park, Peter J.;Chin, Lynda;Schultz, Nikolaus;Sinha, Rileen;Ciriello, Giovanni;Cerami, Ethan;Gross, Benjamin;Jacobsen, Anders;Gao, Jianjiong;Aksoy, B. Arman;Weinhold, Nils;Ramirez, Ricardo;Taylor, Barry S.;Antipin, Yevgeniy;Reva, Boris;Shen, Ronglai;Mo, Qianxing;Seshan, Venkatraman;Paik, Paul K.;Ladanyi, Marc;Sander, Chris;Akbani, Rehan;Zhang, Nianxiang;Broom, Bradley M.;Casasent, Tod;Unruh, Anna;Wakefield, Chris;Cason, R. Craig;Baggerly, Keith A.;Weinstein, John N.;Haussler, David;Benz, Christopher C.;Stuart, Joshua M.;Zhu, Jingchun;Szeto, Christopher;Scott, Gary K.;Yau, Christina;Ng, Sam;Goldstein, Ted;Waltman, Peter;Sokolov, Artem;Ellrott, Kyle;Collisson, Eric A.;Zerbino, Daniel;Wilks, Christopher;Ma, Singer;Craft, Brian;Wilkerson, Matthew D.;Auman, J. Todd;Hoadley, Katherine A.;Du, Ying;Cabanski, Christopher;Walter, Vonn;Singh, Darshan;Wu, Junyuan;Gulabani, Anisha;Bodenheimer, Tom;Hoyle, Alan P.;Simons, Janae V.;Soloway, Matthew G.;Mose, Lisle E.;Jefferys, Stuart R.;Balu, Saianand;Marron, J. S.;Liu, Yufeng;Wang, Kai;Liu, Jinze;Prins, Jan F.;Hayes, D. Neil;Perou, Charles M.;Creighton, Chad J.;Zhang, Yiqun;Travis, William D.;Rekhtman, Natasha;Yi, Joanne;Aubry, Marie C.;Cheney, Richard;Dacic, Sanja;Flieder, Douglas;Funkhouser, William;Illei, Peter;Myers, Jerome;Tsao, Ming-Sound;Penny, Robert;Mallery, David;Shelton, Troy;Hatfield, Martha;Morris, Scott;Yena, Peggy;Shelton, Candace;Sherman, Mark;Paulauskis, Joseph;Meyerson, Matthew;Baylin, Stephen B.;Govindan, Ramaswamy;Akbani, Rehan;Azodo, Ijeoma;Beer, David;Bose, Ron;Byers, Lauren A.;Carbone, David;Chang, Li-Wei;Chiang, Derek;Chu, Andy;Chun, Elizabeth;Collisson, Eric;Cope, Leslie;Creighton, Chad J.;Danilova, Ludmila;Ding, Li;Getz, Gad;Hammerman, Peter S.;Hayes, D. Neil;Hernandez, Bryan;Herman, James G.;Heymach, John;Ida, Cristiane;Imielinski, Marcin;Johnson, Bruce;Jurisica, Igor;Kaufman, Jacob;Kosari, Farhad;Kucherlapati, Raju;Kwiatkowski, David;Ladanyi, Marc;Lawrence, Michael S.;Maher, Christopher A.;Mungall, Andy;Ng, Sam;Pao, William;Peifer, Martin;Penny, Robert;Robertson, Gordon;Rusch, Valerie;Sander, Chris;Schultz, Nikolaus;Shen, Ronglai;Siegfried, Jill;Sinha, Rileen;Sivachenko, Andrey;Sougnez, Carrie;Stoll, Dominik;Stuart, Joshua;Thomas, Roman K.;Tomaszek, Sandra;Tsao, Ming-Sound;Travis, William D.;Vaske, Charles;Weinstein, John N.;Weisenberger, Daniel;Wheeler, David;Wigle, Dennis A.;Wilkerson, Matthew D.;Wilks, Christopher;Yang, Ping;Zhang, Jianjua John;Jensen, Mark A.;Sfeir, Robert;Kahn, Ari B.;Chu, Anna L.;Kothiyal, Prachi;Wang, Zhining;Snyder, Eric E.;Pontius, Joan;Pihl, Todd D.;Ayala, Brenda;Backus, Mark;Walton, Jessica;Baboud, Julien;Berton, Dominique L.;Nicholls, Matthew C.;Srinivasan, Deepak;Raman, Rohini;Girshik, Stanley;Kigonya, Peter A.;Alonso, Shelley;Sanbhadti, Rashmi N.;Barletta, Sean P.;Greene, John M.;Pot, David A.;Tsao, Ming-Sound;Bandarchi-Chamkhaleh, Bizhan;Boyd, Jeff;Weaver, JoEllen;Wigle, Dennis A.;Azodo, Ijeoma A.;Tomaszek, Sandra C.;Aubry, Marie Christine;Ida, Christiane M.;Yang, Ping;Kosari, Farhad;Brock, Malcolm V.;Rogers, Kristen;Rutledge, Marian;Brown, Travis;Lee, Beverly;Shin, James;Trusty, Dante;Dhir, Rajiv;Siegfried, Jill M.;Potapova, Olga;Fedosenko, Konstantin V.;Nemirovich-Danchenko, Elena;Rusch, Valerie;Zakowski, Maureen;Iacocca, Mary V.;Brown, Jennifer;Rabeno, Brenda;Czerwinski, Christine;Petrelli, Nicholas;Fan, Zhen;Todaro, Nicole;Eckman, John;Myers, Jerome;Rathmell, W. Kimryn;Thorne, Leigh B.;Huang, Mei;Boice, Lori;Hill, Ashley;Penny, Robert;Mallery, David;Curley, Erin;Shelton, Candace;Yena, Peggy;Morrison, Carl;Gaudioso, Carmelo;Bartlett, Johnm. S.;Kodeeswaran, Sugy;Zanke, Brent;Sekhon, Harman;David, Kerstin;Juhl, Hartmut;Van Le, Xuan;Kohl, Bernard;Thorp, Richard;Tien, Nguyen Viet;Van Bang, Nguyen;Sussman, Howard;Phu, Bui Duc;Hajek, Richard;PhiHung, Nguyen;Khan, Khurram Z.;Muley, Thomas;Shaw, Kenna R. Mills;Sheth, Margi;Yang, Liming;Buetow, Ken;Davidsen, Tanja;Demchok, John A.;Eley, Greg;Ferguson, Martin;Dillon, Laura A. L.;Schaefer, Carl;Guyer, Mark S.;Ozenberger, Bradley A.;Palchik, Jacqueline D.;Peterson, Jane;Sofia, Heidi J.;Thomson, Elizabeth;Meyerson, Matthew
通讯作者：
Meyerson, Matthew

Distributed Adaptive Fuzzy Control for Nonlinear Multiagent Systems Via Sliding Mode Observers

通过滑模观测器的非线性多智能体系统的分布式自适应模糊控制

DOI：
10.1109/tcyb.2015.2496963
发表时间：
2016-12
期刊：
IEEE Transactions on Cybernetics
影响因子：
11.8
作者：
Shen, Qikun;Shi, Peng;Shi, Yan
通讯作者：
Shi, Yan

Analysis of a reaction-diffusion host-pathogen model with horizontal transmission

水平传播的反应扩散宿主病原体模型分析

DOI：
10.1016/j.jmaa.2019.123481
发表时间：
2020-01-01
期刊：
JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS
影响因子：
1.3
作者：
Shi, Yan;Gao, Jianguo;Wang, Jinliang
通讯作者：
Wang, Jinliang

A carbon dot based biosensor for melamine detection by fluorescence resonance energy transfer

DOI：
10.1016/j.snb.2014.05.058
发表时间：
2014-10-01
期刊：
SENSORS AND ACTUATORS B-CHEMICAL
影响因子：
8.4
作者：
Daia, Haichao;Shi, Yan;Li, Zhuang
通讯作者：
Li, Zhuang

Towards Practical Application of Li-S Battery with High Sulfur Loading and Lean Electrolyte: Will Carbon-Based Hosts Win This Race?

DOI：
10.1007/s40820-023-01120-7
发表时间：
2023-06-07
期刊：
NANO-MICRO LETTERS
影响因子：
26.6
作者：
Gong, Yi;Li, Jing;Yang, Kai;Li, Shaoyin;Xu, Ming;Zhang, Guangpeng;Shi, Yan;Cai, Qiong;Li, Huanxin;Zhao, Yunlong
通讯作者：
Zhao, Yunlong