Computational analyses of transcriptome regulation on RNA level

RNA水平转录组调控的计算分析

• 批准号: 341546-2012
• 负责人: Meyer, Irmtraud
• 金额: $ 1.89万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=505724
• 关键词: Computational; analyses; transcriptome; regulation; RNA

My Bioinformatics group investigates the transcriptome of organisms such as the human, and how it is regulated. The transcriptome corresponds to the set of genes that are activated in a given cell. It consists of so-called transcripts, linear RNA molecules that either encode a protein product or function as so-called RNA genes. Both classes of molecules, i.e. proteins and RNA genes, are key to determining the state of a cell. In contrast to proteins and their interactions, comparatively little is known about the transcriptome and how it is regulated.

我的生物信息学小组研究生物体的转录组，如人类，以及它是如何调节的。转录组对应于在给定细胞中被激活的一组基因。它由所谓的转录物，线性RNA分子组成，这些分子要么编码蛋白质产物，要么作为所谓的RNA基因发挥作用。这两类分子，即蛋白质和RNA基因，是决定细胞状态的关键。与蛋白质及其相互作用相反，人们对转录组及其调控方式知之甚少。