The calcium-sensing receptor and integrins

钙敏感受体和整合素

• 批准号: 41874-2012
• 负责人: Hampson, David
• 金额: $ 2.04万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=505799
• 关键词: calcium; sensing; receptor; integrins

The calcium-sensing receptor (CaSR) is a G-protein coupled receptors (GPCR) that is activated by cations, particularly calcium, and assists in the regulation of calcium levels in the body. It is highly expressed in endocrine cells including parathyroid chief cells and thyroid C-cells where it inhibits the secretion of parathyroid hormone and promotes the secretion of calcitonin respectively, thereby reciprocally regulating two opposing regulators of whole body calcium metabolism. However, recent studies have shown that the CaSR is required for the growth of neuronal processes in the central nervous system.

钙敏感受体 (CaSR) 是一种 G 蛋白偶联受体 (GPCR)，可被阳离子（特别是钙）激活，有助于调节体内钙水平。 它在甲状旁腺主细胞和甲状腺C细胞等内分泌细胞中高表达，分别抑制甲状旁腺激素的分泌和促进降钙素的分泌，从而相互调节全身钙代谢的两个相反的调节因子。 然而，最近的研究表明，CaSR 是中枢神经系统神经元过程生长所必需的。