Sensing active movement of the self: reconsidering the cellular basis kinesthesia

感知自我的主动运动:重新考虑细胞基础运动感觉

基本信息

  • 批准号:
    10417741
  • 负责人:
  • 金额:
    $ 61.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-05-06 至 2026-01-31
  • 项目状态:
    未结题

项目摘要

Abstract The sense of movement (kinesthesia) provides an interoceptive internal readout of our physical actions in space and is essential for our ability to move fluidly and effectively through our environment. Despite kinesthesia's importance in motor function and self-reference, our understanding of this sense is plagued by glaring knowledge gaps and inconsistencies. Movement sensations are traditionally believed to be a specialized function of type Ia muscle spindle afferents. Yet, the apparent disconnect between the peripheral coding properties of this receptor and the sensory stimuli known to evoke a sense of movement have raised questions regarding their primary role in kinesthesia. Although proprioceptive interventions provide functional motor improvements for many conditions such as stroke, Parkinson's disease, focal dystonia, peripheral neuropathies, and musculoskeletal injuries, the lack of a clear scientific foundation for kinesthesia impacts our understanding of sensory-motor deficits and prevents important breakthroughs from translating into clinical successes and targeted intervention strategies. From our recent work we have multiple lines of evidence that suggest there may be sensory muscle receptors, outside of the traditional muscle spindles and Golgi tendon organs that exhibit features consistent with a kinesthetic sensor. First, our peripheral electrophysiological recordings in rat demonstrate a population of fast- conducting rapidly-adapting afferents, that are distinct from muscle spindle and Golgi tendon organ afferents, yet are selectively activated in the frequency bandwidth associated with kinesthetic illusions. Second, our immunological analyses in mouse skeletal muscle reveal a new population of large caliber Calbindin28k+ afferents that do not associate with muscle spindle or Golgi tendon organ receptors but instead terminate in free endings that spread out alongside extrafusal muscle fibers. In a movement-perception study with human neural- machine interface amputees, we found that vibration-induce illusory kinesthetic percepts were linked to muscle contraction not elongation. These results were corroborated in a human stroke model where we amplified kinesthetic perception linked to active muscle contraction which resulted in improved reaching trajectories. With these observations we hypothesize that there are candidate muscle sensory afferents, distinct from type Ia afferents, which selectively respond to muscle fiber contraction. The studies in this proposal will explore the relationships between the response properties and physical characteristics of these candidate kinesthetic receptors and the traditionally defined muscle sensory receptors using genetic, histological, and electrophysiological approaches. Additionally, we will examine this systems functionality with respect to contractile features and its ability to serve as a stimulus for active movement sensing. The discovery and evaluation of the cellular basis of kinesthesia will fundamentally transform our understanding of sensory-motor control and, by extension, will impact design strategies for advanced neural-machine interface prosthetic devices for amputees, as well as other disorders with sensory-motor deficiencies such as stroke.
摘要

项目成果

期刊论文数量(0)
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Paul D. Marasco其他文献

Setting the pace: insights and advancements gained while preparing for an FES bike race
  • DOI:
    10.1186/s12984-017-0326-y
  • 发表时间:
    2017-11-17
  • 期刊:
  • 影响因子:
    5.200
  • 作者:
    John McDaniel;Lisa M. Lombardo;Kevin M. Foglyano;Paul D. Marasco;Ronald J. Triolo
  • 通讯作者:
    Ronald J. Triolo
The application of neuroprosthesis in restoration of unilateral facial nerve paralysis: A scoping review
  • DOI:
    10.1016/j.bjps.2024.11.006
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Trisha Shang;Paul D. Marasco;Peng Ding
  • 通讯作者:
    Peng Ding

Paul D. Marasco的其他文献

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{{ truncateString('Paul D. Marasco', 18)}}的其他基金

Sensing active movement of the self: reconsidering the cellular basis kinesthesia
感知自我的主动运动:重新考虑细胞基础运动感觉
  • 批准号:
    10618908
  • 财政年份:
    2022
  • 资助金额:
    $ 61.42万
  • 项目类别:
Ethical Considerations in Animal Study Translation
动物研究翻译中的伦理考虑
  • 批准号:
    10790093
  • 财政年份:
    2022
  • 资助金额:
    $ 61.42万
  • 项目类别:
Advanced Materials to Improve Moisture Management for Prosthetic Socket Liners
先进材料可改善假肢接受腔衬垫的水分管理
  • 批准号:
    9192453
  • 财政年份:
    2017
  • 资助金额:
    $ 61.42万
  • 项目类别:
Restoring Upper Limb Movement Sense to Amputees; a Move Towards Natural Control o
恢复截肢者上肢运动感觉;
  • 批准号:
    8775031
  • 财政年份:
    2013
  • 资助金额:
    $ 61.42万
  • 项目类别:
Restoring upper limb movement sense to amputees; a move towards natural control o
使截肢者恢复上肢运动感觉;
  • 批准号:
    8412370
  • 财政年份:
    2012
  • 资助金额:
    $ 61.42万
  • 项目类别:

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