Sensing active movement of the self: reconsidering the cellular basis kinesthesia

感知自我的主动运动:重新考虑细胞基础运动感觉

基本信息

  • 批准号:
    10417741
  • 负责人:
  • 金额:
    $ 61.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-05-06 至 2026-01-31
  • 项目状态:
    未结题

项目摘要

Abstract The sense of movement (kinesthesia) provides an interoceptive internal readout of our physical actions in space and is essential for our ability to move fluidly and effectively through our environment. Despite kinesthesia's importance in motor function and self-reference, our understanding of this sense is plagued by glaring knowledge gaps and inconsistencies. Movement sensations are traditionally believed to be a specialized function of type Ia muscle spindle afferents. Yet, the apparent disconnect between the peripheral coding properties of this receptor and the sensory stimuli known to evoke a sense of movement have raised questions regarding their primary role in kinesthesia. Although proprioceptive interventions provide functional motor improvements for many conditions such as stroke, Parkinson's disease, focal dystonia, peripheral neuropathies, and musculoskeletal injuries, the lack of a clear scientific foundation for kinesthesia impacts our understanding of sensory-motor deficits and prevents important breakthroughs from translating into clinical successes and targeted intervention strategies. From our recent work we have multiple lines of evidence that suggest there may be sensory muscle receptors, outside of the traditional muscle spindles and Golgi tendon organs that exhibit features consistent with a kinesthetic sensor. First, our peripheral electrophysiological recordings in rat demonstrate a population of fast- conducting rapidly-adapting afferents, that are distinct from muscle spindle and Golgi tendon organ afferents, yet are selectively activated in the frequency bandwidth associated with kinesthetic illusions. Second, our immunological analyses in mouse skeletal muscle reveal a new population of large caliber Calbindin28k+ afferents that do not associate with muscle spindle or Golgi tendon organ receptors but instead terminate in free endings that spread out alongside extrafusal muscle fibers. In a movement-perception study with human neural- machine interface amputees, we found that vibration-induce illusory kinesthetic percepts were linked to muscle contraction not elongation. These results were corroborated in a human stroke model where we amplified kinesthetic perception linked to active muscle contraction which resulted in improved reaching trajectories. With these observations we hypothesize that there are candidate muscle sensory afferents, distinct from type Ia afferents, which selectively respond to muscle fiber contraction. The studies in this proposal will explore the relationships between the response properties and physical characteristics of these candidate kinesthetic receptors and the traditionally defined muscle sensory receptors using genetic, histological, and electrophysiological approaches. Additionally, we will examine this systems functionality with respect to contractile features and its ability to serve as a stimulus for active movement sensing. The discovery and evaluation of the cellular basis of kinesthesia will fundamentally transform our understanding of sensory-motor control and, by extension, will impact design strategies for advanced neural-machine interface prosthetic devices for amputees, as well as other disorders with sensory-motor deficiencies such as stroke.
摘要 运动感(动觉)提供了我们在空间中的物理行为的内感受性内部读出 这对我们在环境中流畅有效地移动至关重要。尽管动觉 重要性的运动功能和自我参考,我们对这种感觉的理解是困扰着耀眼的知识 差距和不一致。运动感觉在传统上被认为是Ia型的一种特殊功能 肌梭传入然而,这种受体的外围编码特性 而已知的能唤起运动感的感官刺激也引发了关于其主要作用的问题 在动觉上。虽然本体感觉干预提供了许多条件下的功能运动改善 例如中风、帕金森病、局灶性肌张力障碍、周围神经病变和肌肉骨骼损伤, 缺乏明确的动觉科学基础影响了我们对感觉运动缺陷的理解, 阻止重要突破转化为临床成功和有针对性的干预策略。 从我们最近的工作中,我们有多条证据表明可能存在感觉肌肉受体, 在传统的肌梭和高尔基体腱器官之外, 动觉传感器首先,我们在大鼠中的外周电生理记录显示了一群快速- 传导快速适应传入,其不同于肌梭和高尔基体腱器官传入, 但在与动觉错觉相关的频率带宽中被选择性地激活。二是我们 小鼠骨骼肌中的免疫学分析揭示了大口径钙结合蛋白28 k+的新群体 不与肌梭或高尔基体腱器官受体相关,而是终止于游离的 沿着梭外肌纤维伸展的末端。在一项运动感知研究中, 机器接口截肢者,我们发现振动引起的错觉动觉知觉与肌肉有关, 收缩而不是伸长。这些结果在我们放大的人类中风模型中得到了证实。 动觉感知与主动肌肉收缩有关,这导致改进的到达轨迹。与 根据这些观察,我们假设存在与Ia型不同的候选肌肉感觉传入 选择性地对肌纤维收缩作出反应的传入神经。 本研究将探讨响应特性与物理特性之间的关系, 这些候选动觉受体和传统定义的肌肉感觉受体的特征 使用遗传学、组织学和电生理学方法。此外,我们将研究这些系统 关于收缩特征的功能及其作为主动运动感测刺激的能力。 动觉细胞基础的发现和评估将从根本上改变我们的理解 并将影响高级神经机器接口的设计策略 用于截肢者的假肢装置,以及具有感觉运动缺陷的其他疾病,如中风。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Paul D. Marasco其他文献

Setting the pace: insights and advancements gained while preparing for an FES bike race
  • DOI:
    10.1186/s12984-017-0326-y
  • 发表时间:
    2017-11-17
  • 期刊:
  • 影响因子:
    5.200
  • 作者:
    John McDaniel;Lisa M. Lombardo;Kevin M. Foglyano;Paul D. Marasco;Ronald J. Triolo
  • 通讯作者:
    Ronald J. Triolo
The application of neuroprosthesis in restoration of unilateral facial nerve paralysis: A scoping review
  • DOI:
    10.1016/j.bjps.2024.11.006
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Trisha Shang;Paul D. Marasco;Peng Ding
  • 通讯作者:
    Peng Ding

Paul D. Marasco的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Paul D. Marasco', 18)}}的其他基金

Sensing active movement of the self: reconsidering the cellular basis kinesthesia
感知自我的主动运动:重新考虑细胞基础运动感觉
  • 批准号:
    10618908
  • 财政年份:
    2022
  • 资助金额:
    $ 61.42万
  • 项目类别:
Ethical Considerations in Animal Study Translation
动物研究翻译中的伦理考虑
  • 批准号:
    10790093
  • 财政年份:
    2022
  • 资助金额:
    $ 61.42万
  • 项目类别:
Advanced Materials to Improve Moisture Management for Prosthetic Socket Liners
先进材料可改善假肢接受腔衬垫的水分管理
  • 批准号:
    9192453
  • 财政年份:
    2017
  • 资助金额:
    $ 61.42万
  • 项目类别:
Restoring Upper Limb Movement Sense to Amputees; a Move Towards Natural Control o
恢复截肢者上肢运动感觉;
  • 批准号:
    8775031
  • 财政年份:
    2013
  • 资助金额:
    $ 61.42万
  • 项目类别:
Restoring upper limb movement sense to amputees; a move towards natural control o
使截肢者恢复上肢运动感觉;
  • 批准号:
    8412370
  • 财政年份:
    2012
  • 资助金额:
    $ 61.42万
  • 项目类别:

相似海外基金

Understanding the Heightened Amputation Risk Among People Experiencing Homelessness: A Population-based Cohort Study
了解无家可归者截肢风险升高:一项基于人群的队列研究
  • 批准号:
    480010
  • 财政年份:
    2023
  • 资助金额:
    $ 61.42万
  • 项目类别:
    Operating Grants
Collaborative Research: An Integrated, Proactive, and Ubiquitous Prosthetic Care Robot for People with Lower Limb Amputation: Sensing, Device Designing, and Control
合作研究:针对下肢截肢患者的集成、主动、无处不在的假肢护理机器人:传感、设备设计和控制
  • 批准号:
    2246672
  • 财政年份:
    2023
  • 资助金额:
    $ 61.42万
  • 项目类别:
    Standard Grant
Collaborative Research: An Integrated, Proactive, and Ubiquitous Prosthetic Care Robot for People with Lower Limb Amputation: Sensing, Device Designing, and Control
合作研究:针对下肢截肢患者的集成、主动、无处不在的假肢护理机器人:传感、设备设计和控制
  • 批准号:
    2246671
  • 财政年份:
    2023
  • 资助金额:
    $ 61.42万
  • 项目类别:
    Standard Grant
Advancing measurement of physical function in upper limb amputation
推进上肢截肢身体功能的测量
  • 批准号:
    10749083
  • 财政年份:
    2023
  • 资助金额:
    $ 61.42万
  • 项目类别:
Collaborative Research: An Integrated, Proactive, and Ubiquitous Prosthetic Care Robot for People with Lower Limb Amputation: Sensing, Device Designing, and Control
合作研究:针对下肢截肢患者的集成、主动、无处不在的假肢护理机器人:传感、设备设计和控制
  • 批准号:
    2246673
  • 财政年份:
    2023
  • 资助金额:
    $ 61.42万
  • 项目类别:
    Standard Grant
Establishing the Relationship Between Muscle Quality and Joint Loading for Individuals with Transtibial Amputation
建立小腿截肢患者的肌肉质量和关节负荷之间的关系
  • 批准号:
    10677236
  • 财政年份:
    2023
  • 资助金额:
    $ 61.42万
  • 项目类别:
Preventing Amputation through Management of Diabetic Foot; Working with Industry to generate supply chains in an LMIC setting (Uganda) for low-cost fo
通过糖尿病足管理预防截肢;
  • 批准号:
    2883969
  • 财政年份:
    2023
  • 资助金额:
    $ 61.42万
  • 项目类别:
    Studentship
Myoelectric upper limb prosthesis with multiple degrees of freedom using targeted muscle reinnervation surgery for traumatic amputation
多自由度肌电上肢假肢,采用靶向肌肉神经支配手术治疗创伤性截肢
  • 批准号:
    22K16723
  • 财政年份:
    2022
  • 资助金额:
    $ 61.42万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Diabetes Lower Extremity Complications Research and Training Network in Foot Ulcer and Amputation Prevention (DIALECT)
糖尿病下肢并发症足部溃疡和截肢预防研究与培训网络 (DIALECT)
  • 批准号:
    EP/X02699X/1
  • 财政年份:
    2022
  • 资助金额:
    $ 61.42万
  • 项目类别:
    Research Grant
An automatically-adjusting prosthetic socket for people with transtibial amputation
适用于小腿截肢患者的自动调节假肢接受腔
  • 批准号:
    10364108
  • 财政年份:
    2022
  • 资助金额:
    $ 61.42万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了