Defining tissue-specific regulation of peroxisome formation/function in Drosophila melanogaster

过氧体是细胞内的结构，调节重要的过程，特别是脂代谢和活性氧的解毒。从对酵母等分离细胞的研究中，我们知道有12-32个“基本”基因是形成过氧化物酶所必需的。然而，我们也表明，过氧化物体的丢失在形成果蝇(果蝇)不同组织的不同类型中会引起不同的影响。果蝇通常在实验室里被用来研究形成整个动物所需的基本细胞过程。在一百多年的科学史中，果蝇被用来确定基因是如何调节形成复杂器官的不同类型细胞的发育的。

Peroxisomes are structures within cells that regulate important processes, notably lipid metabolism and the detoxification of reactive oxygen. From studies of isolated cells like yeast, we know that there are 12-32 "basic" genes necessary for peroxisome formation. However, we have also shown that loss of peroxisomes causes different effects in the different types that form the various tissues of Drosophila melanogaster (fruit flies). Fruit flies are commonly used in the laboratory to study basic cellular processes that are required to form an entire animal. There is over one hundred years of scientific history where Drosophila has been used to establish how genes regulate development of the different types of cells that form complex organs.