Defining tissue-specific regulation of peroxisome formation/function in Drosophila melanogaster

定义果蝇过氧化物酶体形成/功能的组织特异性调节

• 批准号: 386086-2012
• 负责人: Simmonds, Andrew
• 金额: $ 2.04万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=595913
• 关键词: Defining; tissue; specific; regulation; peroxisome

Peroxisomes are structures within cells that regulate important processes, notably lipid metabolism and the detoxification of reactive oxygen. From studies of isolated cells like yeast, we know that there are 12-32 "basic" genes necessary for peroxisome formation. However, we have also shown that loss of peroxisomes causes different effects in the different types that form the various tissues of Drosophila melanogaster (fruit flies). Fruit flies are commonly used in the laboratory to study basic cellular processes that are required to form an entire animal. There is over one hundred years of scientific history where Drosophila has been used to establish how genes regulate development of the different types of cells that form complex organs.

过氧化物酶体是细胞内调节重要过程的结构，特别是脂质代谢和活性氧的解毒。从对酵母等分离细胞的研究中，我们知道有12-32个过氧化物酶体形成所必需的“基本”基因。然而，我们也已经表明，过氧化物酶体的损失导致不同类型的不同影响，形成不同的组织的果蝇（果蝇）。果蝇通常在实验室中用于研究形成整个动物所需的基本细胞过程。在超过一百年的科学史中，果蝇被用来确定基因如何调节形成复杂器官的不同类型细胞的发育。