Effect of heavy metals on aryl hydrocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
基本信息
- 批准号:250139-2012
- 负责人:
- 金额:$ 2.48万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2012
- 资助国家:加拿大
- 起止时间:2012-01-01 至 2013-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Humans are exposed to numerous stressors, including heavy metals, products of combustion, pesticides, herbicides, and other environmental pollutants. To ensure survival in the face of such challenges, mammalian cells have evolved a variety of inducible genetic programs that enable them to adapt to the presence of harmful foreign compounds. These programs entail upregulation of discrete batteries of genes for foreign compounds metabolizing enzymes, foreign compounds transporters, and various protective proteins that allow an increased rate of foreign compounds elimination from the body, restoration of normal homeostasis, and removal of damaged macromolecules. Rarely is the response regulated by one transcription factor; rather, it is generally a coordinated effort between two or more transcription factors. Among the factors that mediate adaptation to foreign compounds, the aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2) have been widely studied. Historically, the AhR has been associated with toxicity and carcinogenesis, whereas Nrf2 is associated with cell protection. Understanding the cross-talk between these two transcription factors can be exploited to therapeutic advantage or to improve chemopreventive strategies. My long-term objectives is to understand the potential outcome upon exposure to heavy metals and environmental pollutants, which commonly co-exist in the environment, on the expression of genes that is involved in the cellular response to toxicants and oxidative stress. This research uses a collaborative and multidisciplinary approach to elucidate the cellular and molecular mechanisms responsible for the modulation of genes that is involved in the cellular response to toxicants. This research may reveal novel points of intervention to be exploited in the development of new therapies for the treatment and prevention of heavy metals toxicity.
人类暴露于许多压力源,包括重金属、燃烧产物、杀虫剂、除草剂和其他环境污染物。为了确保在面对这些挑战时生存,哺乳动物细胞已经进化出各种可诱导的遗传程序,使它们能够适应有害外来化合物的存在。这些程序需要上调外源化合物代谢酶、外源化合物转运体和各种保护性蛋白质的独立基因电池,这些蛋白质允许增加外源化合物从体内清除的速度,恢复正常的体内平衡,并去除受损的大分子。很少有应答由一个转录因子调控;相反,它通常是两个或多个转录因子之间的协调作用。在介导外源化合物适应的因子中,芳烃受体(AhR)和核因子红系2相关因子2 (Nrf2)被广泛研究。从历史上看,AhR与毒性和致癌有关,而Nrf2与细胞保护有关。了解这两种转录因子之间的串扰可以用于治疗优势或改进化学预防策略。我的长期目标是了解暴露于重金属和环境污染物(它们通常共存于环境中)对参与细胞对毒物和氧化应激反应的基因表达的潜在结果。本研究采用协作和多学科的方法来阐明负责基因调节的细胞和分子机制,参与细胞对毒物的反应。这项研究可能揭示新的干预点,可用于开发新的治疗和预防重金属毒性的疗法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ElKadi, Ayman其他文献
ElKadi, Ayman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ElKadi, Ayman', 18)}}的其他基金
Effect of heavy metals on aryl hyrdocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
RGPIN-2017-03844 - 财政年份:2021
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hyrdocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
RGPIN-2017-03844 - 财政年份:2020
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hyrdocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
RGPIN-2017-03844 - 财政年份:2019
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hyrdocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
RGPIN-2017-03844 - 财政年份:2018
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hyrdocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
RGPIN-2017-03844 - 财政年份:2017
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hydrocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
250139-2012 - 财政年份:2014
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hydrocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
250139-2012 - 财政年份:2013
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hydrocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
250139-2007 - 财政年份:2011
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Development of direct electrochemical antibody-based biosensor detection system for airborne foot and mouth disease virus
基于电化学抗体的空气传播口蹄疫病毒直接生物传感器检测系统的研制
- 批准号:
428277-2011 - 财政年份:2011
- 资助金额:
$ 2.48万 - 项目类别:
Engage Grants Program
Effect of heavy metals on aryl hydrocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
250139-2007 - 财政年份:2010
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
小分子抑制剂Thiotert通过TRX-NCOA4-FTH通路调控MDS细胞铁死亡
- 批准号:LBY23H080005
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
Probing quark gluon plasma by heavy quarks in heavy-ion collisions
- 批准号:11805087
- 批准年份:2018
- 资助金额:30.0 万元
- 项目类别:青年科学基金项目
狭叶香蒲重金属转运蛋白HMA(Heavy Metal ATPase)类基因的分离鉴定及功能分析
- 批准号:31701931
- 批准年份:2017
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
高分辨SAS图像的统计特性及新成像算法研究
- 批准号:61162012
- 批准年份:2011
- 资助金额:52.0 万元
- 项目类别:地区科学基金项目
水下多途信道下的SAS图像统计特性及成像新算法研究
- 批准号:61062013
- 批准年份:2010
- 资助金额:8.0 万元
- 项目类别:地区科学基金项目
植物重金属污染的磁学响应及机理研究
- 批准号:40972216
- 批准年份:2009
- 资助金额:50.0 万元
- 项目类别:面上项目
红树对重金属的定位累积及耦合微观分析与耐受策略研究
- 批准号:30970527
- 批准年份:2009
- 资助金额:35.0 万元
- 项目类别:面上项目
高速网络环境下Heavy Hitter的行为测量与分析
- 批准号:60803142
- 批准年份:2008
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Effect of heavy metals on aryl hyrdocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
RGPIN-2017-03844 - 财政年份:2021
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hyrdocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
RGPIN-2017-03844 - 财政年份:2020
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hyrdocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
RGPIN-2017-03844 - 财政年份:2019
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hyrdocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
RGPIN-2017-03844 - 财政年份:2018
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hyrdocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
RGPIN-2017-03844 - 财政年份:2017
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of Alcohol Use on Waterpipe Smoking Patterns and Toxicant Exposure
饮酒对水烟吸烟模式和有毒物质暴露的影响
- 批准号:
9350154 - 财政年份:2016
- 资助金额:
$ 2.48万 - 项目类别:
Effect of Alcohol Use on Waterpipe Smoking Patterns and Toxicant Exposure
饮酒对水烟吸烟模式和有毒物质暴露的影响
- 批准号:
9192802 - 财政年份:2016
- 资助金额:
$ 2.48万 - 项目类别:
Effect of heavy metals on aryl hydrocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
250139-2012 - 财政年份:2014
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Effect of heavy metals on aryl hydrocarbon receptor-regulated genes
重金属对芳烃受体调节基因的影响
- 批准号:
250139-2012 - 财政年份:2013
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Interactive Effect of Environmental Exposures and Alcohol in the Navajo Birth Coh
环境暴露和酒精对纳瓦霍出生COH的交互影响
- 批准号:
8496240 - 财政年份:2013
- 资助金额:
$ 2.48万 - 项目类别: