Regulation of mammalian neuroprogenitor cell proliferation and differentiation

哺乳动物神经祖细胞增殖和分化的调节

基本信息

  • 批准号:
    386553-2011
  • 负责人:
  • 金额:
    $ 2.55万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2012
  • 资助国家:
    加拿大
  • 起止时间:
    2012-01-01 至 2013-12-31
  • 项目状态:
    已结题

项目摘要

The mammalian nervous system is made up of billions of cells. During development and throughout the lifetime of mammals such as in humans, a group of cells known as - neuroprogenitor cells, have specialized roles to form and to replenish the cells of the nervous system. These neuroprogenitor cells require both genetic and environmental factors to function properly, in a complex biological process known as neurogenesis. Although neurogenesis occurs in both mammalian and non-mammalian vertebrates, our understanding of the genetic mechanisms still remains largely unknown. The premise of this research stems from a gene, known as NPAS3, that Dr. Kamnasaran cloned and characterized previously. The NPAS3 gene functions to regulate the expression of other genes in a cell. Dr. Kamnasaran recently discovered NPAS3 functions in the neuroprogenitor cells human fetal brains, and with a role in neurogenesis. This research seeks to gain a better understanding of inherent genetic mechanisms in the biology of human fetal neuroprogenitor cells. Dr. Kamnasaran plans to first determine what proteins regulate the expression of the human NPAS3 gene in fetal neuroprogenitor cells. He also plans to discover what DNA sequence the NPAS3 protein recognizes to regulate the expression of genes in cells, and what regions of the protein are necessary to mediate function. Finally, he will undertake studies to discover pathways that the NPAS3 gene interacts with to better understand the process of human fetal neurogenesis. This body of work is original, novel and highly significant, and is anticipated to uncover new pathways and mechanisms implicated in the biology of human fetal neuroprogenitor cells.
哺乳动物的神经系统由数十亿个细胞组成。 在哺乳动物如人类的发育过程中和整个生命周期中,一组称为神经祖细胞的细胞具有形成和补充神经系统细胞的专门作用。 这些神经祖细胞需要遗传和环境因素才能正常发挥功能,这是一个复杂的生物学过程,称为神经发生。 虽然神经发生发生在哺乳动物和非哺乳动物的脊椎动物,我们的理解的遗传机制仍然在很大程度上是未知的。 这项研究的前提源于一个名为NPAS3的基因,Kamnasaran博士以前克隆并鉴定了该基因。 NPAS3基因的功能是调节细胞中其他基因的表达。 Kamnasaran博士最近发现NPAS3在人类胎儿大脑的神经祖细胞中发挥作用,并在神经发生中发挥作用。 这项研究旨在更好地了解人类胎儿神经祖细胞生物学中的内在遗传机制。 Kamnasaran博士计划首先确定哪些蛋白质调节胎儿神经祖细胞中人类NPAS3基因的表达。 他还计划发现NPAS3蛋白识别哪些DNA序列来调节细胞中基因的表达,以及蛋白质的哪些区域是介导功能所必需的。 最后,他将进行研究,以发现NPAS3基因相互作用的途径,以更好地了解人类胎儿神经发生的过程。 这项工作是原创的,新颖的和非常重要的,预计将揭示人类胎儿神经祖细胞生物学中涉及的新途径和机制。

项目成果

期刊论文数量(0)
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Kamnasaran, Deepak其他文献

Prenatal diagnosis and identification of heterozygous frameshift mutation in PRRX1 in an infant with agnathia-otocephaly
  • DOI:
    10.1002/pd.3910
  • 发表时间:
    2012-09-01
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Donnelly, Meghan;Todd, Emily;Kamnasaran, Deepak
  • 通讯作者:
    Kamnasaran, Deepak
Human Schwannomas Express Activated Platelet-Derived Growth Factor Receptors and c-kit and Are Growth Inhibited by Gleevec (Imatinib Mesylate)
  • DOI:
    10.1158/0008-5472.can-08-4475
  • 发表时间:
    2009-06-15
  • 期刊:
  • 影响因子:
    11.2
  • 作者:
    Mukherjee, Joydeep;Kamnasaran, Deepak;Guha, Abhijit
  • 通讯作者:
    Guha, Abhijit
Preclinical evaluation of dipotassium bisperoxo (picolinato) oxovanadate V for the treatment of pediatric low-grade gliomas
  • DOI:
    10.2217/fon.13.73
  • 发表时间:
    2013-08-01
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Ajeawung, Norbert Fonya;Faure, Robert;Kamnasaran, Deepak
  • 通讯作者:
    Kamnasaran, Deepak
GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model
Viability screen on pediatric low grade glioma cell lines unveils a novel anti-cancer drug of the steroid biosynthesis inhibitor family
  • DOI:
    10.1016/j.canlet.2012.11.034
  • 发表时间:
    2013-03-01
  • 期刊:
  • 影响因子:
    9.7
  • 作者:
    Ajeawung, Norbert Fonya;Maltais, Rene;Kamnasaran, Deepak
  • 通讯作者:
    Kamnasaran, Deepak

Kamnasaran, Deepak的其他文献

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{{ truncateString('Kamnasaran, Deepak', 18)}}的其他基金

Regulation of mammalian neuroprogenitor cell proliferation and differentiation
哺乳动物神经祖细胞增殖和分化的调节
  • 批准号:
    386553-2011
  • 财政年份:
    2014
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Regulation of mammalian neuroprogenitor cell proliferation and differentiation
哺乳动物神经祖细胞增殖和分化的调节
  • 批准号:
    386553-2011
  • 财政年份:
    2013
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Regulation of mammalian neuroprogenitor cell proliferation and differentiation
哺乳动物神经祖细胞增殖和分化的调节
  • 批准号:
    386553-2011
  • 财政年份:
    2011
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Development of an embryonic stem cell in vivo assay for genes which cause astrocytomas
开发胚胎干细胞体内导致星形细胞瘤基因的检测方法
  • 批准号:
    301545-2004
  • 财政年份:
    2005
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Postdoctoral Fellowships
Development of an embryonic stem cell in vivo assay for genes which cause astrocytomas
开发胚胎干细胞体内导致星形细胞瘤基因的检测方法
  • 批准号:
    301545-2004
  • 财政年份:
    2004
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Postdoctoral Fellowships

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会议:2024年哺乳动物合成生物学研讨会
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