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Development of specific ubiquitin-based inhibitors targeting oncogenic deubiquitinating enzyme USP1

Development of specific ubiquitin-based inhibitors targeting oncogenic deubiquitinating enzyme USP1
开发针对致癌去泛素化酶 USP1 的特异性泛素抑制剂
批准号：
254956
负责人：
Zhang Wei
金额：
$9.83万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-02-01 至 2015-02-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=254956&lang=en
关键词：
Cancer Therapy Combinatorial Libraries Deubiquitination High Throughput Screening Osteosarcoma Phage Display Protein Engineering Ubiquitin Usp1

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英文摘要
Effective strategies to treat cancer rely on our ability to interfere with cellular processes that are deregulated in tumors. One such biological process is the regulation of protein stability by a small protein called ubiquitin, which attaches to other p
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