The ADVIA® 2120i Hematology System

ADVIA® 2120i 血液学系统

• 批准号: 441384-2013
• 负责人: Field, Catherine
• 金额: $ 9万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=506232
• 关键词: ADVIA; 2120i; Hematology; System

The applicants' NSERC research programs study how nutrients and other components in our diet help obtain and maintain overall health. These programs focus on changes in nutrition on metabolism and immune development of lipids, carbohydrates and vitamins on physiological changes across the lifespan. The health outcomes that are being studied by the applicants in their different research programs involve the risk of diseases including diabetes and cardiovascular disease, allergies and complications of pregnancy. To address these important research goals the applicant's need to accurately measure small changes of compounds in blood caused by diet and disease state. The ADVIA® 2120i hematology analyzer is requested in this grant application. It is a specialized instrument that can measure changes in white and red blood cells in both humans and animal models of research, used to study basic metabolism and physiology. This state-of-the-art instrument has the unique feature to measure critical blood parameters in multiple species, including humans, mice, rats and pigs. Changes in the number, type and structure of red and white blood cells are indicators of how diet alters metabolism. This type of measurement is routinely used to monitor conditions such as infection and anemia in both humans and the animal models of research. This equipment also enables a researcher to measure the amount and physiology of whole blood including white and red blood cell counts, neutrophils, basophils, eosinophils and platelets all indices healthy and normal immune responses. The ADVIA® 2120i would be the only instrument on the University of Alberta campus that has this capacity. We propose to not only use this instrument in our research programs but it will also be used to train our technicians, undergraduate, graduate, and post-graduate students. These trainees will be employed in diverse careers in academia, industry, government and healthcare. The ADVIA® 2120i system will become part of a core nutrition facility that is run by the Nutrition Research Group in the Department of Agricultural, Food and Nutritional Science at the University of Alberta.

申请者的NSERC研究项目研究我们饮食中的营养素和其他成分如何帮助获得和维持整体健康。这些计划侧重于营养变化对血脂、碳水化合物和维生素新陈代谢和免疫发育的影响，以及对整个生命周期的生理变化的影响。申请者在他们的不同研究项目中正在研究的健康结果包括糖尿病和心血管疾病、过敏和怀孕并发症等疾病的风险。为了达到这些重要的研究目标，申请人需要准确地测量饮食和疾病状态引起的血液中化合物的微小变化。本次资助申请要求使用ADVIA®2120i血细胞分析仪。它是一种专门的仪器，可以测量人类和动物研究模型中白细胞和红细胞的变化，用于研究基本新陈代谢和生理学。这种最先进的仪器具有独特的功能，可以测量多种物种的关键血液参数，包括人类、小鼠、大鼠和猪。红细胞和白细胞的数量、类型和结构的变化是饮食如何改变新陈代谢的指标。这种类型的测量通常用于监测研究的人类和动物模型中的感染和贫血等情况。该设备还使研究人员能够测量全血的数量和生理指标，包括白细胞和红细胞计数、中性粒细胞、嗜碱性粒细胞、嗜酸性粒细胞和血小板，所有这些指标都是健康和正常的免疫反应。ADVIA®2120i将是艾伯塔大学校园内唯一具有此功能的仪器。我们建议不仅在我们的研究项目中使用该仪器，而且还将用于培训我们的技术人员、本科生、研究生和研究生。这些受训人员将在学术界、工业界、政府和医疗保健行业从事不同的职业。ADVIA®2120i系统将成为核心营养设施的一部分，该设施由艾伯塔大学农业、食品和营养科学系营养研究小组运营。