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Functional properties of the paraFacial Respiratory group within the brainstem respiratory network

脑干呼吸网络内面旁呼吸群的功能特性

基本信息

批准号：
435843-2013
负责人：
Pagliardini, Silvia
金额：
$ 2.48万
依托单位：
University of Alberta
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2018
资助国家：
加拿大
起止时间：
2018-01-01 至 2019-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=661395
关键词：
Functional properties paraFacial Respiratory group

项目摘要

Respiratory activity is generated by rhythmically active nerve cells (neurons) located in the lower brainstem (medulla); these neurons control the continuous rhythmic contraction of respiratory muscles from birth until the last breath of life. For a number of years, the preBötzinger Complex (preBötC), a group of inspiratory neurons in the medulla, has been thought to be the only system that underlies respiration. In this model, inspiration is the active phase of the respiratory cycle. Recent evidence, however, has shown that a second region, the para Facial Respiratory Group (pFRG), may also have a key function in respiratory rhythmogenesis and this area has been specifically proposed to have a critical role in the generation of expiratory activity (active recruitment of expiratory muscles), whereas preBötC is necessary for inspiration. **While preBötC degeneration, drug-induced inhibition or impaired development affects inspiratory activity in both experimental animals and humans, the fundamental role of pFRG in respiratory rhythm generation is still under debate.**This proposal aims to identify the location, physiological characteristics, state dependent modulation and the potential function of pFRG, in order to have a better understanding of how respiratory activity is generated in mammals and paced by two opposing respiratory rhythm generating centers. This work will increase our mechanistic understanding of the indispensable neural control of respiratory musculature in air breathing mammals.**************

呼吸活动是由位于下脑干（髓质）的节律性活跃的神经细胞（神经元）产生的;这些神经元控制呼吸肌从出生到生命的最后一次呼吸的连续节律性收缩。多年来，前伯青格复合体（preBötC），一组延髓中的吸气神经元，一直被认为是呼吸的唯一基础系统。在该模型中，吸气是呼吸循环的活跃阶段。然而，最近的证据表明，第二个区域，旁面部呼吸群（paraFacial Respiratory Group，pFRG），也可能在呼吸节律发生中起关键作用，该区域被特别提出在产生呼气活动（呼气肌的主动募集）中起关键作用，而preBötC是吸气所必需的。** 虽然preBötC变性，药物诱导的抑制或发育受损会影响实验动物和人类的吸气活动，但pFRG在呼吸节律产生中的基本作用仍在争论中。本研究的目的是确定pFRG的位置、生理特征、状态依赖性调节和潜在功能，以便更好地理解哺乳动物呼吸活动是如何产生的，以及两个相对的呼吸节律产生中心是如何起搏的。这项工作将增加我们对呼吸空气的哺乳动物呼吸肌肉组织不可或缺的神经控制的机械理解。