Regulatory effects of extracellular substrate stiffness with mechanical oscillatory stretch on contractile phenotype and function of airway smooth muscle cells

机械振荡拉伸细胞外基质硬度对气道平滑肌细胞收缩表型和功能的调节作用

• 批准号: 252726
• 负责人: Wise Rachel
• 金额: $ 1.27万
• 依托单位: Dalhousie University (Nova Scotia)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-02-01 至 2013-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=252726&lang=en
• 关键词: Airway Smooth Muscle; Airway Wall Remodelling; Asthma; Extracellular Matrix; Mechanotransduction

The human airway is composed of many cell types including smooth muscle cells. In asthma, the airway is both thickened and overactive and narrows too much causing potentially dangerous airway obstruction. The reason for this airway narrowing in asthma is

人体气道由多种细胞类型组成，包括平滑肌细胞。在哮喘中，气道既增厚又过度活跃，并且过度狭窄，导致潜在危险的气道阻塞。哮喘气道变窄的原因是