Muscarinic receptor antagonism as a novel mechanism for sensory nerve repair.

毒蕈碱受体拮抗作用作为感觉神经修复的新机制。

• 批准号: 259745
• 负责人: Fernyhough Paul
• 金额: $ 8.09万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-03-01 至 2014-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=259745&lang=en
• 关键词: Animal Models; Chemotherapy-Induced Neuropathy; Confocal Imaging; In Vivo Electrophysiology; Mitochondria; Muscarinic Receptors; Nerve Regeneration; Pain Sensitivity; Peripheral Neuropathy; Sensory Neuron

Objective Diabetic sensory neuropathy and chemotherapy-induced peripheral neuropathy (CIPN) are neurodegenerative diseases characterized by loss of nerve fibers in the skin. Both diseases cause significant pain and eventually lead to sensory loss. The imp

客观化 糖尿病感觉神经病变和化疗引起的周围神经病变(CIPN)是以皮肤神经纤维丢失为特征的神经退行性疾病。这两种疾病都会引起巨大的疼痛，并最终导致感觉丧失。小鬼