Mechanisms of Aspergillus induced chronic airway disease

曲霉菌诱发慢性气道疾病的机制

• 批准号: 252045
• 负责人: Sheppard Donald C
• 金额: $ 39.01万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-03-01 至 2017-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=252045&lang=en
• 关键词: Aspergillus Fumigatus; Chronic Lung Disease; Cystic Fibrosis; Inflammation; Mast Cells

The mold Aspergillus fumigatus colonizes the lungs of up to half of patients with cystic fibrosis, whose lung function then worsens. Antifungal therapy is rarely successful in eradicating the fungus, suggesting a need for new therapies for this condition.

霉菌烟曲霉菌在多达一半的囊性纤维化患者的肺部定植，这些患者的肺功能随后下降。抗真菌治疗很少能成功根除真菌，这表明需要针对这种情况的新疗法。