Evaluation of high-resolution ultrasound imaging methods for quantification of tumour volume and vascularization

癌症的侵袭性需要同时对肿瘤进行多重打击的治疗。人类癌症的动物模型被用来了解新的抗癌治疗的作用，并评估其在人类患者中使用的安全性。然而，大多数使用动物模型的研究依赖于有限数量的测量，这些测量通常只评估治疗对肿瘤生长的影响。其他可以阐明治疗有效性的生理参数通常只能在研究动物牺牲后才能测量。ARM治疗公司正在开发治疗乳腺癌和前列腺癌的新疗法，这种疗法通过几种不同的机制攻击肿瘤。因此，ARM需要在活体动物模型中评估这些机制中的每一种。这一需求可以通过生物医学成像技术来满足，该技术可以测量完整肿瘤的多种生物参数。

The aggressive nature of cancer requires treatments that simultaneously deliver multiple blows to a tumour. Animal models of human cancers are used to understand the action of new anti-cancer treatments and assess their safety for use in human patients. However, the majority of studies using animal models rely on a limited number of measurements that typically only assess the treatment's effect on tumour growth. Other physiological parameters that can shed light on a treatment's effectiveness can usually only be measured upon sacrifice of the research animals. Armour Therapeutics Inc. is developing novel treatments for breast and prostate cancers that attack tumours through several different mechanisms. Armour is therefore in need of methods to evaluate each of these mechanisms in live animal models. This need can be met by biomedical imaging technologies that measure multiple biological parameters in intact tumours.