Evaluation of high-resolution ultrasound imaging methods for quantification of tumour volume and vascularization

评估用于量化肿瘤体积和血管化的高分辨率超声成像方法

• 批准号: 430477-2012
• 负责人: Lacefield, James
• 金额: $ 1.82万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=510899
• 关键词: Evaluation; resolution; ultrasound; imaging; methods

The aggressive nature of cancer requires treatments that simultaneously deliver multiple blows to a tumour. Animal models of human cancers are used to understand the action of new anti-cancer treatments and assess their safety for use in human patients. However, the majority of studies using animal models rely on a limited number of measurements that typically only assess the treatment's effect on tumour growth. Other physiological parameters that can shed light on a treatment's effectiveness can usually only be measured upon sacrifice of the research animals. Armour Therapeutics Inc. is developing novel treatments for breast and prostate cancers that attack tumours through several different mechanisms. Armour is therefore in need of methods to evaluate each of these mechanisms in live animal models. This need can be met by biomedical imaging technologies that measure multiple biological parameters in intact tumours.

癌症的侵袭性需要同时对肿瘤进行多次打击的治疗。 人类癌症的动物模型用于了解新的抗癌治疗的作用，并评估其在人类患者中使用的安全性。 然而，大多数使用动物模型的研究依赖于有限数量的测量，通常仅评估治疗对肿瘤生长的影响。 其他可以揭示治疗效果的生理参数通常只能在处死研究动物时测量。 Armour Therapeutics Inc正在开发通过几种不同机制攻击肿瘤的乳腺癌和前列腺癌的新疗法。 因此，Armour需要在活体动物模型中评估这些机制中的每一种的方法。 这种需要可以通过测量完整肿瘤中的多个生物参数的生物医学成像技术来满足。