Systematic stem cell bioprocess engineering

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Cell-based therapeutics are motivated by the observation that many cell transplantation procedures yield significant benefits to patients. Unfortunately however, the cells and/or tissues needed to treat the numbers of patients that could benefit from cell transplantation significantly outstrip availability from donors. Stem cells have generated much excitement as a potential source of cells for drug development and cell-based therapeutics because of their ability to self-renew (divide while maintaining stem cell properties) and differentiate into functional cells (such as blood or heart cells). The proposed studies will continue our efforts to develop a mechanism-based technological platform for the generation of therapeutically relevant cells from pluripotent stem cells.