Stem Cell Bioengineering

干细胞生物工程

• 批准号: 1000220904-2010
• 负责人: Zandstra, Peter
• 金额: $ 9.11万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642495
• 关键词: Stem; Cell; Bioengineering

Stem cells are responsible for tissue development, repair and regeneration. These properties make stem cells an important therapeutic target for regenerative medicine. Research in the Zandstra Laboratory uses engineering and biological strategies to develop new technologies capable of robustly controlling of stem cell growth and commitment to functional lineages such as blood and heart cells. Using computational models to understand stem cell fate responses, and bioreactors and bioengineering strategies to tightly regulate the cellular microenvironment, this research provides an innovative training environment for young scientists and is leading to the development of clinically and industrially relevant technologies to benefit Canadians.

干细胞负责组织发育、修复和再生。这些特性使干细胞成为再生医学的重要治疗靶点。Zandstra实验室的研究使用工程和生物学策略来开发能够强有力地控制干细胞生长和承诺功能谱系（如血液和心脏细胞）的新技术。利用计算模型来理解干细胞命运反应，利用生物反应器和生物工程策略来严格调节细胞微环境，该研究为年轻科学家提供了一个创新的培训环境，并正在引领临床和工业相关技术的发展，造福加拿大人。