The role of MEF2 in memory

MEF2在记忆中的作用

• 批准号: 250250-2010
• 负责人: Josselyn, Sheena
• 金额: $ 3.64万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514534
• 关键词: role; MEF2; memory

Understanding how the brain encodes and stores memory is a fundamental goal of neuroscience. Changes in synaptic structure and efficacy are thought to underlie learning and memory. In the brain, more than 90% of excitatory synapses occur on dendritic spines. In this way, dendritic spines serve as the postsynaptic component for the vast majority of central nervous system excitatory synapses. Indeed, the notion that dendritic spines serve as a physical substrate of long term memory was first posited by Santiago Ramón y Cajal who described their morphology in detail over a century ago.

了解大脑如何编码和存储记忆是神经科学的一个基本目标。 突触结构和功效的变化被认为是学习和记忆的基础。 在大脑中，超过90%的兴奋性突触发生在树突棘上。以这种方式，树突棘作为绝大多数中枢神经系统兴奋性突触的突触后成分。 事实上，树突棘作为长期记忆的物理基底的概念首先由圣地亚哥拉蒙·卡哈尔提出，他在世纪前详细描述了树突棘的形态。