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Neural circuitry for sound-guided auditory plasticity: tonotopic cortico-subcortical loop combined with cholinergic inputs

声音引导听觉可塑性的神经回路：音调皮质-皮质下环路与胆碱能输入相结合

基本信息

批准号：
261338-2009
负责人：
Yan, Jun
金额：
$ 2.91万
依托单位：
University of Calgary
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2012
资助国家：
加拿大
起止时间：
2012-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514579
关键词：
Neural circuitry sound guided auditory

项目摘要

Learning and experience continuously shape the brain (referred to as plasticity). This is a learning process that is an essential brain function for our everyday life. It is believed that auditory learning or experience induces significant changes of neuronal function in the central auditory system. This change is called auditory plasticity that is guided by acquired sounds (sound-guided auditory plasticity). This suggests that the brain can adapt to changes in acoustic environment: but how? The proposed study will examine how the built-in neural wiring in the brain underlies the sound-guided auditory plasticity. We specifically focus on the reciprocal projections between the cortex and subcortical nuclei and the cholinergic projections to the auditory system. Auditory plasticity will be assessed by the changes in the receptive fields of auditory neurons with an electrophysiological approach. We expect that the reciprocal projections (between the auditory cortex and subcortical nuclei) combined with its cholinergic inputs constitutes an integrative functional unit responsible for inducing and coordinating sound-guided auditory plasticity. Results from the proposed study, together with our previous findings, will elucidate a comprehensive neural circuit responsible for sound-guided auditory plasticity. This established circuitry will significantly improve our understanding of the neural basis of learning.

学习和经验不断塑造大脑（称为可塑性）。这是一个学习的过程，是我们日常生活中必不可少的大脑功能。人们认为听觉学习或听觉体验会引起中枢听觉系统神经元功能的显著变化。这种变化被称为听觉可塑性，它是由习得性声音引导的（声音引导的听觉可塑性）。这表明大脑可以适应声音环境的变化：但如何适应呢？这项拟议的研究将研究大脑中内置的神经线路如何成为声音引导的听觉可塑性的基础。我们特别关注皮层和皮层下核之间的相互投射以及对听觉系统的胆碱能投射。听觉可塑性将通过电生理学方法评估听觉神经元感受野的变化。我们预计，听觉皮层和皮层下核之间的相互投射与其胆碱能输入相结合，构成了一个综合功能单元，负责诱导和协调声音引导的听觉可塑性。这项研究的结果，连同我们之前的发现，将阐明一个全面的神经回路负责声音引导的听觉可塑性。这种已建立的电路将大大提高我们对学习的神经基础的理解。