Program in chemoenzymatic asymmetric synthesis: amaryllidaceae and morphine alkaloids, chiral synthons, and new reagents for asymmetric synthesis

化学酶不对称合成项目：石蒜科和吗啡生物碱、手性合成子和不对称合成新试剂

• 批准号: 262022-2008
• 负责人: Hudlicky, Tomas
• 金额: $ 6.05万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514637
• 关键词: Program; chemoenzymatic; asymmetric; synthesis; amaryllidaceae

The overall focus of our program is the development of efficient protocols for asymmetric synthesis of compounds of medicinal importance. The investigation of new methods of environmentally benign manufacturing or "green" synthesis benefits from the combination of biological methods with sound strategic planning of chemical pathways. The proposed research represents a well-integrated approach to two important groups: the morphine alkaloids and the Amaryllidaceae alkaloids, as well as medicinally useful derivatives of both. In addition, new biotransformations will be pursued in order to provide chiral building blocks and a chiral version of the Burgess reagent will be applied to the total synthesis of balanol.

我们计划的总体重点是开发高效的不对称合成药用化合物的方案。对环境无害的制造或“绿色”合成新方法的研究得益于生物方法与化学途径的合理战略规划的结合。这项拟议的研究代表了对两个重要类别的良好整合的方法：吗啡生物碱和石蒜科生物碱，以及这两个生物碱的医学上有用的衍生物。此外，为了提供手性构建块，将进行新的生物转化，手性版本的Burgess试剂将应用于全合成巴拉诺。