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Program in chemoenzymatic asymmetric synthesis: amaryllidaceae and morphine alkaloids, chiral synthons, and new reagents for asymmetric synthesis

Program in chemoenzymatic asymmetric synthesis: amaryllidaceae and morphine alkaloids, chiral synthons, and new reagents for asymmetric synthesis
化学酶不对称合成项目：石蒜科和吗啡生物碱、手性合成子和不对称合成新试剂
批准号：
262022-2008
负责人：
Hudlicky, Tomas
金额：
$6.05万
依托单位：
Brock University
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-01-01 至 2013-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514637
关键词：
Programchemoenzymaticasymmetricsynthesisamaryllidaceae

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英文摘要
The overall focus of our program is the development of efficient protocols for asymmetric synthesis of compounds of medicinal importance. The investigation of new methods of environmentally benign manufacturing or "green" synthesis benefits from the combination of biological methods with sound strategic planning of chemical pathways. The proposed research represents a well-integrated approach to two important groups: the morphine alkaloids and the Amaryllidaceae alkaloids, as well as medicinally useful derivatives of both. In addition, new biotransformations will be pursued in order to provide chiral building blocks and a chiral version of the Burgess reagent will be applied to the total synthesis of balanol.
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Organic Synthesis and Biocatalysis
  • 批准号：
    CRC-2016-00268
  • 项目类别：
    Canada Research Chairs
  • 资助金额：
    $7.6万
  • 财政年份：
    2022
  • 负责人：
    Hudlicky, Tomas
  • 依托单位：
    Brock University
Program in the chemoenzymatic synthesis of alkaloids and medicinal agents and the development of new chiral building blocks, asymmetric protocols, and reagents
  • 批准号：
    RGPIN-2018-03723
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $5.76万
  • 财政年份：
    2022
  • 负责人：
    Hudlicky, Tomas
  • 依托单位：
    Brock University
Program in the chemoenzymatic synthesis of alkaloids and medicinal agents and the development of new chiral building blocks, asymmetric protocols, and reagents
  • 批准号：
    RGPIN-2018-03723
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $5.76万
  • 财政年份：
    2021
  • 负责人：
    Hudlicky, Tomas
  • 依托单位：
    Brock University
Organic Synthesis And Biocatalysis
  • 批准号：
    CRC-2016-00268
  • 项目类别：
    Canada Research Chairs
  • 资助金额：
    $14.57万
  • 财政年份：
    2021
  • 负责人：
    Hudlicky, Tomas
  • 依托单位：
    Brock University
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