Role of matrix metalloproteinase (MMP)-2 in regulating smooth muscle contraction

基质金属蛋白酶（MMP）-2在调节平滑肌收缩中的作用

• 批准号: 403045-2011
• 负责人: Schulz, Richard
• 金额: $ 2.91万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=515555
• 关键词: Role; matrix; metalloproteinase; MMP; regulating

Matrix metalloproteinases (MMPs) are proteins known to cause structural and functional changes in blood vessels by cutting other proteins into smaller pieces. MMP-2 is found in vascular smooth muscle and endothelial cells and has been studied for its important role in the regulation of vascular contraction. MMPs are produced without any activity and they need other proteins or oxidative stress to activate them.

基质金属蛋白酶（MMPs）是一种已知的蛋白质，通过将其他蛋白质切割成更小的碎片，导致血管的结构和功能变化。MMP-2存在于血管平滑肌和内皮细胞中，并因其在血管收缩调节中的重要作用而被研究。MMPs的产生没有任何活性，它们需要其他蛋白质或氧化应激来激活它们。