A gold-nanoparticle kit for the development of tailor-made radiodiagnostics and radio-therapeutics

用于开发定制放射诊断和放射治疗的金纳米颗粒套件

• 批准号: 412893-2011
• 负责人: Schirrmacher, Ralf
• 金额: $ 10.4万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=515638
• 关键词: gold; nanoparticle; kit; development; tailor

This proposal deals with the development of a new platform for imaging and therapy of various diseases. Basically, very small particles made of gold (gold nanoparticles) will be loaded with different molecules. Some of those molecules will transport the particle to a tumor, or to the brain (depending on the molecule chosen and on the application needed). Some other molecules will allow to put a radioactive tag onto the gold-particle. This radioactive tag can either be used to localize the particle (thus helping to diagnose a disease with the imaging modality positron emission tomography) or to deliver radioactivity to an area of the body (thus treating a disease, similar to radiation therapy).

该提案涉及开发用于各种疾病的成像和治疗的新平台。基本上，由金制成的非常小的颗粒（金纳米颗粒）将装载不同的分子。这些分子中的一些将把粒子运送到肿瘤或大脑（取决于所选择的分子和所需的应用）。一些其他的分子将允许把放射性标签放在金粒子上。这种放射性标签可以用于定位粒子（从而有助于用成像模式正电子发射断层扫描诊断疾病）或将放射性传递到身体的某个区域（从而治疗疾病，类似于放射疗法）。