Mechanisms of Protection and Informed Target Discovery for Gene and Stem Cell Therapy in Sepsis

脓毒症基因和干细胞治疗的保护机制和知情靶标发现

• 批准号: 274123
• 负责人: Dos Santos Claudia C
• 金额: $ 7.29万
• 依托单位: Unity Health Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-09-01 至 2013-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=274123&lang=en
• 关键词: Animal Models; Bioinformatics; Gene Expression Profiling; Inflammation; Mesenchymal Stem Cells; Microrna Profiling; Primary Cells; Sepsis; Transcription Factors; Transgenic Mice/Knockout Mice

In Canada, severe sepsis strikes young and old alike with an incidence of ~75,000 cases per year, a mortality of 30-40%. Given the rising numbers (8.7%/yr), by 2026 about 34,000 Ontarians are expected to be in the intensive care unit (ICU) on life support

在加拿大，严重的败血症对年轻人和老年人都有影响，每年的发病率约为75000例，死亡率为30-40%。鉴于这一数字的增长（每年8.7%），到2026年，预计约有34,000名安大略省人将在重症监护病房（ICU）接受生命支持