Lipid bilayer interactions and organization at ambient and high pressure

环境压力和高压下的脂质双层相互作用和组织

• 批准号: 9031-2009
• 负责人: Morrow, Michael
• 金额: $ 2.04万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=521215
• 关键词: Lipid; bilayer; interactions; organization; ambient

Lipid molecules dispersed in water assemble into thin layers with polar headgroups on the outside and flexible hydrocarbon chains inside. These bilayers are important as soft materials and as the structural basis for cell membranes. By applying wideline NMR to model systems with deuterated components, we learn how composition and component structure affect the organization, mechanical properties, and motion of components in such materials and address questions of both material and biological significance.

分散在水中的脂类分子聚集成薄层，外层带有极性头基，内部有柔性碳氢链。这些双层作为软材料和细胞膜的结构基础是很重要的。通过将宽线核磁共振应用于含氚组分的模型体系，我们了解了组成和组分结构如何影响此类材料中组分的组织、机械性能和运动，并解决了具有材料和生物意义的问题。