Using video force microscopy (VFM) to determine the forces that drive morphogenetic movements of cells and tissues

使用视频力显微镜 (VFM) 确定驱动细胞和组织形态发生运动的力

• 批准号: 36514-2012
• 负责人: Brodland, Wayne
• 金额: $ 2.26万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=521383
• 关键词: Using; video; force; microscopy; VFM

Most people do not realize how important cell and tissue movements are to human health. However, it is through such movements that organs and other critical structures form during early embryo development, that wounds heal, that cells leave a primary cancer tumour and establish metastases, and that proper structure and function arise in engineered tissues. These movements are driven by sub-cellular structural components, and alterations to the forces they generate can significantly impact health outcomes. One could conceive pharmaceutical and other means to therapeutically manipulate these forces, but we must have practical ways to measure them if we are to evaluate proposed interventions, and that is the goal of my research program.

大多数人没有意识到细胞和组织运动对人类健康有多么重要。然而，正是通过这样的运动，器官和其他关键结构在早期胚胎发育期间形成，伤口愈合，细胞离开原发癌症肿瘤并建立转移，适当的结构和功能在工程组织中产生。这些运动是由亚细胞结构成分驱动的，它们所产生的力量的变化可以显著影响健康结果。人们可以设想药物和其他手段来治疗操纵这些力量，但如果我们要评估拟议的干预措施，我们必须有实用的方法来衡量它们，这就是我的研究计划的目标。