Promoting Genetic Counseling among African American Women with Hereditary Risk for Breast Cancer

促进有乳腺癌遗传风险的非裔美国女性的遗传咨询

• 批准号: 10664032
• 负责人: Vida Ann Henderson
• 金额: $ 16.28万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-16 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664032
• 关键词: Address; Affect; African American; Applications Grants; Award; Awareness; BRCA1 gene; Behavioral; Behavioral Model; Breast Cancer Risk Factor; Cancer Center; Chicago; Clinical Research; Counseling; Coupled; DNA Sequence Alteration; Data; Decision Aid; Decision Making; Development; Development Plans; Diffusion; Discipline; Disparity; Distress; Early Diagnosis; Educational workshop; Ensure; Epigenetic Process; Family member; Federally Qualified Health Center; Funding; General Population; Genes; Genetic; Genetic Counseling; Genetic Services; Goals; Grant; Guidelines; High Risk Woman; Illinois; Individual; Inequity; Inherited; Intervention; Knowledge; Lead; Malignant Neoplasms; Mentors; Mentorship; Methods; Minority Women; Mission; Multimedia; Neighborhood Health Center; Not Hispanic or Latino; Pamphlets; Participant; Pathogenicity; Pathway Analysis; Physicians; Population Heterogeneity; Positioning Attribute; Primary Health Care; Productivity; Provider; Psychosocial Factor; Public Health; Public Health Schools; Race; Randomized, Controlled Trials; Recommendation; Research; Research Activity; Research Personnel; Risk; Scientist; Self Determination; Services; Social Network; Structure; Testing; Time; Training; Training Activity; Translational Research; United States; United States Preventative Services Task Force; Universities; Variant; Woman; Work; Writing; cancer genetics; cancer health disparity; cancer prevention; career; career development; cost; design; effectiveness testing; emotional distress; ethnic minority; genetic risk assessment; genetic testing; health service use; hereditary risk; high risk; high risk population; hormone receptor-negative; improved; intrinsic motivation; malignant breast neoplasm; meetings; minority communities; mortality; multidisciplinary; precision medicine; racial minority; risk perception; skill acquisition; skills; social; social relationships; socioeconomics; systemic barrier; theories; tool; tumor; underserved minority; uptake; video coaching

1 The long-term career goal of this K01 project is to gain training and mentorship that will prepare me for a career 2 as an independent and successful externally funded investigator in the field of cancer health disparities. Over 3 the next 5 years, my career objectives are to: 1) develop and lead experimental interventions; 2) gain further 4 expertise in translational science; 3) acquire skills in quantitative analysis, including social network analysis; and 5 4) enhance my ability to write competitive grant applications and increase my scholarly productivity. With my 6 primary mentor, Dr. Marian Fitzgibbon, I have assembled a strong team of co-mentors and advisors (including a 7 biostatistician) to guide me through the proposed training and research activities. The proposed career 8 development plan is structured to ensure that I achieve training milestones through didactic coursework, career 9 development workshops, and attendance at national scientific meetings. The University of Illinois at Chicago 10 (School of Public Health and Cancer Center) are committed to supporting my career development and providing 11 the protected time needed to achieve my career and research goals. The overall objective of this K01 research 12 project is to test the effectiveness of a culturally targeted video, previously developed by our research team, on 13 promoting genetic counseling attendance among African American (AA) women determined to be at high risk for 14 breast cancer through cancer genetic risk assessment at a Federally Qualified Health Center. Uptake of genetic 15 services is particularly low among high-risk AA women, who carry a disproportionate burden of breast cancer 16 mortality. Further, although testing close relatives of individuals who test positive for a pathogenic variant might 17 curtail breast cancer disparities attributable to hereditary risk, it is unclear how counseled or tested individuals 18 influence their social and familial networks. Thus, my central hypothesis is that the culturally targeted video will 19 increase genetic counseling attendance among participants compared to those who receive a genetic counseling 20 brochure. The proposed Specific Aims are to: 1) compare the effects of the video and brochure on genetic 21 counseling attendance among AA women at high risk for breast cancer; 2) test how psychosocial factors 22 (knowledge, intrinsic motivation, risk perception, distress) affect relationships between intervention exposures 23 (video/brochure) and genetic counseling attendance; and 3) compare the impact of intervention exposures 24 (video/brochure) on diffusion of knowledge through social network analysis. My prior training, coupled with the 25 skills that I will acquire during the award period, will equip me to successfully conduct the proposed research 26 and position me to continue my work to address breast cancer disparities that persist among high-risk AA women. 27 28 29 30 31 32

1这个K 01项目的长期职业目标是获得培训和指导，这将为我的职业生涯做好准备 2作为癌症健康差异领域独立且成功的外部资助研究者。超过 3未来5年，我的职业目标是：1）开发和领导实验干预; 2）获得进一步的 4.翻译科学的专业知识; 3）掌握定量分析的技能，包括社会网络分析; 5.提高我撰写有竞争力的基金申请的能力，提高我的学术生产力。和我 6主要的导师，玛丽安·菲茨吉茨博士，我已经组建了一个强大的团队的共同导师和顾问（包括一个 7生物统计学家）指导我完成拟议的培训和研究活动。提议的职业 8发展计划的结构，以确保我通过教学课程，职业生涯实现培训里程碑 9次发展讲习班，并出席国家科学会议。伊利诺伊大学芝加哥分校 10（公共卫生学院和癌症中心）致力于支持我的职业发展，并提供 11.实现我的职业和研究目标所需的受保护的时间。K 01研究的总体目标 12项目是为了测试文化针对性的视频的有效性，以前由我们的研究团队开发， 13促进非裔美国人（AA）妇女的遗传咨询出席确定为高风险， 14乳腺癌通过癌症遗传风险评估在联邦合格的健康中心。遗传吸收 15服务在高危AA妇女中特别低，她们承担着不成比例的乳腺癌负担 16例死亡。此外，尽管检测致病性变异阳性个体的近亲可能 17减少遗传风险导致的乳腺癌差异，目前尚不清楚如何对个人进行咨询或测试 18影响他们的社会和家庭网络。因此，我的中心假设是，文化目标视频将 与接受遗传咨询的人相比，参与者的遗传咨询出席率增加19 20小册子。建议的具体目的是：1）比较视频和手册对遗传的影响 21名患有乳腺癌高风险的AA女性接受咨询; 2）测试心理社会因素如何影响 22（知识，内在动机，风险认知，痛苦）影响干预暴露之间的关系 23（视频/小册子）和遗传咨询出席;和3）比较干预暴露的影响 24（录像/小册子），通过社会网络分析传播知识。我之前的训练，加上 25技能，我将获得在奖励期间，将装备我成功地进行拟议的研究 26并让我继续努力解决高危AA女性中持续存在的乳腺癌差异。 27 28 29 30 31 32

项目成果

Pilot study of a culturally sensitive intervention to promote genetic counseling for breast cancer risk.

• DOI: 10.1186/s12913-022-08193-x
• 发表时间: 2022-06-25
• 期刊: BMC HEALTH SERVICES RESEARCH
• 影响因子: 2.8
• 作者: Henderson, Vida;Madrigal, Jessica M.;Kendall, Le' Chaun;Parekh, Pooja;Newsome, Jennifer;Chukwudozie, Ifeanyi Beverly;Comer-Hagans, De Lawnia;Coffey, Vickii;Grumbach, Giesela;Spencer, Shirley;Rodgers, Carolyn;Kaur, Ravneet;Balay, Lara;Maga, Tara;Ramamonjiarivelo, Zo;Balthazar, Catherine;Winn, Robert;Watson, Karriem;Odoms-Young, Angela;Hoskins, Kent F.
• 通讯作者: Hoskins, Kent F.