Assembly and disassembly of cucumber necrosis virus and role of host components

黄瓜坏死病毒的组装和拆卸以及宿主成分的作用

• 批准号: 43840-2011
• 负责人: Rochon, DAnn
• 金额: $ 2.9万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=521686
• 关键词: Assembly; disassembly; cucumber; necrosis; virus

Plant viruses are responsible for economic loss in a variety of crops worldwide. Several measures to reduce the impact of viruses on crop production are in place, however, plant viruses have proven difficult to control. Research in my laboratory aims to understand specific aspects of the multiplication cycle of a plant virus, and the nature of host components that the virus uses for these processes. Toward this aim, it is proposed to analyze how a plant virus particle disassembles in a plant cell and how the newly synthesized components reassemble to form new virus particles. In addition, it is proposed to investigate which host components the virus interacts with in order to assemble and disassemble. Disassembly of a plant virus is essential for the establishment of infection and assembly of new particles allows the virus to spread throughout and between plants. Understanding these essential aspects of the virus infection cycle will contribute to the development of new strategies for controlling virus infection.

植物病毒是造成世界范围内多种作物经济损失的原因。 已经采取了一些措施来减少病毒对作物生产的影响，但是，植物病毒已被证明难以控制。我实验室的研究旨在了解植物病毒增殖周期的特定方面，以及病毒用于这些过程的宿主成分的性质。 为了实现这一目标，建议分析植物病毒颗粒如何在植物细胞中分解以及新合成的组分如何重新组装以形成新的病毒颗粒。此外，建议研究病毒与哪些宿主组分相互作用以组装和拆卸。植物病毒的传播对于建立感染是必不可少的，新颗粒的组装允许病毒在整个植物中和植物之间传播。了解病毒感染周期的这些基本方面将有助于控制病毒感染的新策略的发展。