Glycomic studies by mass spectrometry

通过质谱法进行糖组学研究

• 批准号: 170241-2011
• 负责人: Perreault, Hélène
• 金额: $ 3.28万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=522773
• 关键词: Glycomic; studies; mass; spectrometry

The genomes of most complex organisms encode more than twenty thousand proteins, which constitute the structural and regulatory building blocks of all their cells and tissues. After protein synthesis by translation of messenger ribonucleic acid, posttranslational addition of oligosaccharides among other possible groups serves critical and diverse biological functions by altering the structure and activity of proteins. Understanding how posttranslational modifications (PTMs) govern protein interactions and assembly is a major goal in the biological sciences.

大多数复杂生物的基因组编码两万多种蛋白质，这些蛋白质构成了它们所有细胞和组织的结构和调控构件。在通过翻译信使核糖核酸合成蛋白质之后，低聚糖的翻译后加成以及其他可能的基团通过改变蛋白质的结构和活性来发挥关键的和多样化的生物学功能。了解翻译后修饰(PTM)如何控制蛋白质的相互作用和组装是生物科学的一个主要目标。