Humanized yeast and the study of anti-apoptosis
人源化酵母及其抗细胞凋亡的研究
基本信息
- 批准号:217502-2009
- 负责人:
- 金额:$ 2.7万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2013
- 资助国家:加拿大
- 起止时间:2013-01-01 至 2014-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The use of yeast in biotechnology is a multi-billion dollar industry. Their use ranges from the production of foodstuff (beer, wine, bread) to the production of bioactive proteins and complex molecules that are used as drugs and additives. A major problem associated with these uses is that yeast cells must be exposed to a variety of environmental stresses that lead to death and serve to increase costs or decrease end product production. We have identified a number of human, mouse and yeast genes that can confer resistance and prevent cell death in response to different death inducing stimuli. We have used stimuli that mimic the stresses encountered by industrial yeast. Thus our research is of importance because it is in line with many industries that are seeking different ways, including increasing apoptosis resistance, to prevent industrial cell death. In addition, our research is part of a major focus on using yeast as a genetic model to uncover the basic cellular machinery involved in regulating the process of programmed cell death in eukaryotic cells. Genetically encoded cell death is a basic cellular process seen in all eukaryotes and understanding its underlying processes will have wide ranging implications for a variety of processes such as development. Yeast is likely to give new insights into this phenomenon since we can use genetic techniques that are not easily applicable to many other organisms.
酵母在生物技术中的应用是一个价值数十亿美元的产业。它们的用途从生产食品(啤酒、葡萄酒、面包)到生产用作药物和添加剂的生物活性蛋白质和复杂分子。与这些用途相关的一个主要问题是,酵母细胞必须暴露于各种导致死亡的环境压力下,从而增加成本或减少最终产品的产量。我们已经确定了一些人类、小鼠和酵母基因,这些基因可以在不同的死亡诱导刺激下赋予抵抗力并防止细胞死亡。我们使用了模拟工业酵母所遇到的压力的刺激物。因此,我们的研究很重要,因为它与许多正在寻求不同方法的行业是一致的,包括增加细胞凋亡抗性,以防止工业细胞死亡。此外,我们的研究是主要关注酵母作为遗传模型的一部分,以揭示真核细胞程序性细胞死亡过程中涉及的基本细胞机制。基因编码的细胞死亡是所有真核生物的基本细胞过程,了解其潜在过程将对发育等各种过程产生广泛的影响。酵母很可能为这一现象提供新的见解,因为我们可以使用不容易适用于许多其他生物的遗传技术。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Greenwood, Michael其他文献
Exploiting redundancy in large materials datasets for efficient machine learning with less data.
- DOI:
10.1038/s41467-023-42992-y - 发表时间:
2023-11-10 - 期刊:
- 影响因子:16.6
- 作者:
Li, Kangming;Persaud, Daniel;Choudhary, Kamal;Decost, Brian;Greenwood, Michael;Hattrick-Simpers, Jason - 通讯作者:
Hattrick-Simpers, Jason
Modeling structural transformations in binary alloys with phase field crystals
- DOI:
10.1103/physrevb.84.064104 - 发表时间:
2011-08-18 - 期刊:
- 影响因子:3.7
- 作者:
Greenwood, Michael;Ofori-Opoku, Nana;Provatas, Nikolas - 通讯作者:
Provatas, Nikolas
Effects of ingesting protein with various forms of carbohydrate following resistance-exercise on substrate availability and markers of anabolism, catabolism, and immunity.
耐药性运动后,摄入各种形式的碳水化合物对底物的可利用性和代谢性,分解代谢和免疫标记的影响。
- DOI:
10.1186/1550-2783-4-18 - 发表时间:
2007-11-12 - 期刊:
- 影响因子:5.1
- 作者:
Kreider, Richard B.;Earnest, Conrad P.;Lundberg, Jennifer;Rasmussen, Christopher;Greenwood, Michael;Cowan, Patricia;Almada, Anthony L. - 通讯作者:
Almada, Anthony L.
Phase-field-crystal methodology for modeling of structural transformations
- DOI:
10.1103/physreve.83.031601 - 发表时间:
2011-03-10 - 期刊:
- 影响因子:2.4
- 作者:
Greenwood, Michael;Rottler, Joerg;Provatas, Nikolas - 通讯作者:
Provatas, Nikolas
Overexpression of oxytocin receptors in the hypothalamic PVN increases baroreceptor reflex sensitivity and buffers BP variability in conscious rats
- DOI:
10.1111/bph.12776 - 发表时间:
2014-10-01 - 期刊:
- 影响因子:7.3
- 作者:
Lozic, Maja;Greenwood, Michael;Japundzic-Zigon, Nina - 通讯作者:
Japundzic-Zigon, Nina
Greenwood, Michael的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Greenwood, Michael', 18)}}的其他基金
Characterization of novel Programmed Cell death (PCD) pathways in yeast
酵母中新型程序性细胞死亡(PCD)途径的表征
- 批准号:
RGPIN-2016-04812 - 财政年份:2021
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Characterization of novel Programmed Cell death (PCD) pathways in yeast
酵母中新型程序性细胞死亡(PCD)途径的表征
- 批准号:
RGPIN-2016-04812 - 财政年份:2020
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Characterization of novel Programmed Cell death (PCD) pathways in yeast
酵母中新型程序性细胞死亡(PCD)途径的表征
- 批准号:
RGPIN-2016-04812 - 财政年份:2019
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Characterization of novel Programmed Cell death (PCD) pathways in yeast
酵母中新型程序性细胞死亡(PCD)途径的表征
- 批准号:
RGPIN-2016-04812 - 财政年份:2018
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Characterization of novel Programmed Cell death (PCD) pathways in yeast
酵母中新型程序性细胞死亡(PCD)途径的表征
- 批准号:
RGPIN-2016-04812 - 财政年份:2017
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Characterization of novel Programmed Cell death (PCD) pathways in yeast
酵母中新型程序性细胞死亡(PCD)途径的表征
- 批准号:
RGPIN-2016-04812 - 财政年份:2016
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Humanized yeast and the study of anti-apoptosis
人源化酵母及其抗细胞凋亡的研究
- 批准号:
217502-2009 - 财政年份:2015
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Humanized yeast and the study of anti-apoptosis
人源化酵母及其抗细胞凋亡的研究
- 批准号:
217502-2009 - 财政年份:2014
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Humanized yeast and the study of anti-apoptosis
人源化酵母及其抗细胞凋亡的研究
- 批准号:
217502-2009 - 财政年份:2012
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Humanized yeast and the study of anti-apoptosis
人源化酵母及其抗细胞凋亡的研究
- 批准号:
217502-2009 - 财政年份:2011
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
信号转导分子PAK4相互作用蛋白质的筛选
- 批准号:30370736
- 批准年份:2003
- 资助金额:20.0 万元
- 项目类别:面上项目
相似海外基金
Humanized yeast as a platform to study human gene function and evolution
人源化酵母作为研究人类基因功能和进化的平台
- 批准号:
RGPIN-2018-05089 - 财政年份:2022
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Humanized yeast as a platform to study human gene function and evolution
人源化酵母作为研究人类基因功能和进化的平台
- 批准号:
RGPIN-2018-05089 - 财政年份:2021
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Humanized yeast as a platform to study human gene function and evolution
人源化酵母作为研究人类基因功能和进化的平台
- 批准号:
RGPIN-2018-05089 - 财政年份:2020
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Humanized yeast as a platform to study human gene function and evolution
人源化酵母作为研究人类基因功能和进化的平台
- 批准号:
RGPIN-2018-05089 - 财政年份:2019
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Humanized yeast as a platform to study human gene function and evolution
人源化酵母作为研究人类基因功能和进化的平台
- 批准号:
RGPIN-2018-05089 - 财政年份:2018
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Humanized yeast as a platform to study human gene function and evolution
人源化酵母作为研究人类基因功能和进化的平台
- 批准号:
DGECR-2018-00228 - 财政年份:2018
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Launch Supplement
Humanized yeast and the study of anti-apoptosis
人源化酵母及其抗细胞凋亡的研究
- 批准号:
217502-2009 - 财政年份:2015
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
Humanized yeast and the study of anti-apoptosis
人源化酵母及其抗细胞凋亡的研究
- 批准号:
217502-2009 - 财政年份:2014
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual
The contribution of fragile site structure to genome instability in humanized yea
脆弱位点结构对人源化基因组不稳定性的贡献
- 批准号:
8367390 - 财政年份:2012
- 资助金额:
$ 2.7万 - 项目类别:
Humanized yeast and the study of anti-apoptosis
人源化酵母及其抗细胞凋亡的研究
- 批准号:
217502-2009 - 财政年份:2012
- 资助金额:
$ 2.7万 - 项目类别:
Discovery Grants Program - Individual