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Oxidative stress induced cell death, cellular senescence

Oxidative stress induced cell death, cellular senescence
氧化应激诱导细胞死亡、细胞衰老
批准号:
238744-2009
负责人:
Pandey, Siyaram
金额:
$1.82万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-01-01 至 2014-12-31

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中文摘要
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英文摘要
Mammalian systems have evolved two powerful programs to abort the multiplication of cells that carry injury to either the main genetic material (DNA), or other important cellular components: replicative senescence and apoptosis. Replicative senescence is a state in which cells are incapable of further division, and apoptosis represents cellular suicide with the systematic part-by-part degradation and removal of the cell without causing injury to the neighbouring cells. The important issues concerning these phenomena are the stimuli that are capable of triggering these programs, as well as the precise biochemical alterations within the cell that mediate them.
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