Oxidative stress induced cell death, cellular senescence

氧化应激诱导细胞死亡、细胞衰老

• 批准号: 238744-2009
• 负责人: Pandey, Siyaram
• 金额: $ 1.82万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=524431
• 关键词: Oxidative; stress; induced; cell; death

Mammalian systems have evolved two powerful programs to abort the multiplication of cells that carry injury to either the main genetic material (DNA), or other important cellular components: replicative senescence and apoptosis. Replicative senescence is a state in which cells are incapable of further division, and apoptosis represents cellular suicide with the systematic part-by-part degradation and removal of the cell without causing injury to the neighbouring cells. The important issues concerning these phenomena are the stimuli that are capable of triggering these programs, as well as the precise biochemical alterations within the cell that mediate them.

哺乳动物系统已经进化出两个强大的程序来中止细胞的增殖，这些细胞携带对主要遗传物质（DNA）或其他重要细胞组分的损伤：复制性衰老和凋亡。复制性衰老是细胞不能进一步分裂的状态，而凋亡代表细胞自杀，细胞系统地逐部分降解和去除细胞而不对邻近细胞造成损伤。关于这些现象的重要问题是能够触发这些程序的刺激，以及介导这些程序的细胞内精确的生化改变。