Food bioactives and bone metabolism

食物生物活性与骨代谢

• 批准号: 238916-2010
• 负责人: Ward, Wendy
• 金额: $ 2.55万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=524498
• 关键词: Food; bioactives; bone; metabolism

Bone tissue begins to deteriorate as the body's ability to produce estrogen and testosterone is compromised with aging. Food bioactives, naturally present in foods such as flaxseed and fish oil, may help preserve normal bone cell function during aging. Food bioactives of particular interest to bone cell metabolism include lignans from flaxseed, and omega-3 fatty acids from flaxseed and fish oil. Flaxseed lignans can have biological activity similar to estrogen that our bodies naturally produce. Diets that contain higher amounts of omega-3 fatty acids have been shown to improve markers of bone status. The goal of the proposed research program is to determine if these food bioactives provide added benefits when provided with current pharmacological agents that help stabilize bone cell activity when it becomes unbalanced during aging. Pharmacological agents of interest include low dose estrogen (at a much lower dose than traditional estrogen therapy that is associated with elevated risk of developing breast cancer and heart disease), and selective estrogen or androgen receptor modulators that have positive effects on bone cell regulation without adverse effects in non-bone tissues. Studies will be conducted using well-established rat models that simulate the physiological changes in bone metabolism that occur in men and women during aging. Food bioactives in combination with pharmacological agents will be provided using these rat models. Findings from this research program may lead to the development of strategies that combine food bioactives and current pharmacological agents to more effectively normalize bone cell metabolism during aging. And specific mechanisms of action in bone cell metabolism will be determined.

随着身体产生雌激素和睾酮的能力随着年龄的增长而受到损害，骨组织开始恶化。天然存在于亚麻籽和鱼油等食品中的食品生物活性物质可能有助于在衰老过程中保持正常的骨细胞功能。对骨细胞代谢特别感兴趣的食物生物活性物质包括来自亚麻籽的木酚素以及来自亚麻籽和鱼油的 omega-3 脂肪酸。亚麻籽木脂素具有与我们身体自然产生的雌激素相似的生物活性。含有较高含量 omega-3 脂肪酸的饮食已被证明可以改善骨骼状态的标志物。拟议研究计划的目标是确定这些食品生物活性物质与当前的药物制剂一起提供是否能提供额外的益处，这些药物在衰老过程中变得不平衡时有助于稳定骨细胞的活性。感兴趣的药理学制剂包括低剂量雌激素（比传统雌激素疗法低得多的剂量，传统雌激素疗法与患乳腺癌和心脏病的风险增加有关），以及对骨细胞调节有积极作用而不对非骨组织产生不利影响的选择性雌激素或雄激素受体调节剂。研究将使用完善的大鼠模型进行，该模型模拟男性和女性在衰老过程中发生的骨代谢的生理变化。将使用这些大鼠模型提供与药物制剂相结合的食品生物活性物质。该研究项目的发现可能会导致结合食品生物活性物质和当前药物制剂的策略的发展，以更有效地使衰老过程中的骨细胞代谢正常化。并将确定骨细胞代谢的具体作用机制。