Bone and Muscle Development

骨骼和肌肉发育

• 批准号: 1000230786-2015
• 负责人: Ward, Wendy
• 金额: $ 7.29万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=692647
• 关键词: Bone; Muscle; Development

The consequence of poor bone health is ever-present for Canadians. We all know of family or friends who cannot hold a grandchild due to chronic pain from vertebral compression fractures, who experience a loss of independence due to limited mobility and physical function, and are at increased risk of anxiety and depression due to these social and functional limitations. This research program primarily uses preclinical models to develop dietary strategies, sometimes in combination with drug therapies, that may support development and maintenance of a strong skeleton throughout life. Stronger bones prevent debilitating fragility fractures, improving quality of life of Canadians.

骨骼健康状况不佳的后果对加拿大人来说一直存在。我们都知道，由于脊椎压缩性骨折引起的慢性疼痛而无法抱孙子的家人或朋友，由于活动能力和身体功能有限而失去独立性，并且由于这些社会和功能限制而增加了焦虑和抑郁的风险。该研究计划主要使用临床前模型来开发饮食策略，有时与药物治疗相结合，这可能会支持一生中强壮骨骼的发育和维持。更强壮的骨骼可以防止脆弱性骨折，提高加拿大人的生活质量。