Linking Innate and Adaptive Immunity: The Role of Eosinophils

连接先天免疫和适应性免疫：嗜酸性粒细胞的作用

• 批准号: 250184-2013
• 负责人: Griebel, Philip
• 金额: $ 2.87万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=524947
• 关键词: Linking; Innate; Adaptive; Immunity; Role

The accepted paradigm for eosinophil function is that they are innate immune effector cells that play a primary role in defence against parasites and contribute to allergic reactions. This paradigm has been challenged by the presence of eosinophils in the small intestine during fetal development and in the absence of parasitic infections. Evidence is emerging that eosinophils play a much broader role in maintaining the homoestasis of mucosal barriers and the induction of adaptive immune responses. These concepts are consistent with the capacity of eosinophils to release a wide variety of cytokines, chemokines, and pro-inflammatory mediators.

嗜酸性粒细胞功能的公认范式是它们是先天免疫效应细胞，在防御寄生虫中发挥主要作用，并有助于过敏反应。这种模式受到了挑战的存在嗜酸性粒细胞在小肠胎儿发育期间和寄生虫感染的情况下。有证据表明，嗜酸性粒细胞在维持粘膜屏障的稳态和诱导适应性免疫应答中发挥更广泛的作用。这些概念与嗜酸性粒细胞释放多种细胞因子、趋化因子和促炎介质的能力一致。