The role of ATF3 in linking innate interleukin-1 activation and adaptive type I interferon responses (B06)

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The mechanisms deciding whether immune reactions remain innate or turn into adaptive immune responses remain unknown. Our preliminary data and molecular data from variants of psoriasis or lupus erythematosus (LE), and some genetic diseases strongly suggest that the balance between IL-1α/IL-1β on one side and IL-6/ATF3 and IFNs on the other determine whether innate immune responses turn into memory responses or not. We will study innate responses and delayed type hypersensitivity reactions in ATF3, IL6, IFNR knockout mice, and correlate these data with the molecular and cellular pattern of either innate or T cell driven variants of psoriasis or LE.