The role of ATF3 in linking innate interleukin-1 activation and adaptive type I interferon responses (B06)

ATF3 在连接先天性白细胞介素 1 激活和适应性 I 型干扰素反应中的作用 (B06)

• 批准号: 273669521
• 金额: --
• 依托单位: Klinik für Dermatologie und Allergologie - Hautklinik
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/273669521?language=en
• 关键词: role; ATF3; linking; innate; interleukin

The mechanisms deciding whether immune reactions remain innate or turn into adaptive immune responses remain unknown. Our preliminary data and molecular data from variants of psoriasis or lupus erythematosus (LE), and some genetic diseases strongly suggest that the balance between IL-1α/IL-1β on one side and IL-6/ATF3 and IFNs on the other determine whether innate immune responses turn into memory responses or not. We will study innate responses and delayed type hypersensitivity reactions in ATF3, IL6, IFNR knockout mice, and correlate these data with the molecular and cellular pattern of either innate or T cell driven variants of psoriasis or LE.

决定免疫反应是保持先天性还是转变为适应性免疫反应的机制仍然未知。我们的初步数据和来自银屑病或红斑狼疮（LE）变体以及一些遗传性疾病的分子数据强烈表明，IL-1α/IL-1β与IL-6/ATF 3和IFN之间的平衡决定了先天免疫应答是否转变为记忆应答。我们将研究ATF 3，IL 6，IFNR敲除小鼠的先天性反应和迟发型超敏反应，并将这些数据与银屑病或LE的先天性或T细胞驱动变体的分子和细胞模式相关联。