Integrative approaches to thermoregulation: behavioural, physiological, and molecular

体温调节的综合方法：行为、生理和分子

• 批准号: 262087-2009
• 负责人: Tattersall, Glenn
• 金额: $ 2.19万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525495
• 关键词: Integrative; approaches; thermoregulation; behavioural; physiological

All animals require oxygen to maintain aerobic metabolism and ultimately to survive. Nonetheless, there are situations, externally or internally generated, where oxygen is limited, called hypoxia. Animals possess numerous adaptations for coping with these kinds of environmental stresses. The goal of my research program is to understand how animals control their body temperature and metabolism during times when a high metabolic rate or high body temperature is impossible or inefficient to sustain, such as during hypoxia, hypothermia, hibernation, torpor or sleep. Currently, where this control resides in the body is unknown. Cells and tissues seem to have built-in mechanisms for regulating metabolism, but the role of the nervous system as the control centre is less well known. The widespread prevalence in the animal kingdom of these reduced metabolic states argues for a great need throughout evolution for the development of alternative physiological strategies for coping with severe environmental conditions. I take a comparative and integrative approach, studying animals that have naturally evolved physiological defences for coping with hypoxia. I have been developing a research program aimed at studying how animals utilise temperature to alter their metabolic needs, since it is well known that cold slows metabolic processes. It turns out that all animals prefer lower body temperatures and exhibit lower metabolism when faced with hypoxia. How this is controlled physiologically and behaviourally, and why all animals exhibit this response, particularly when hypoxia only occurs in certain environments or times of life, is unknown. Understanding this process will shed light on how animals modify and manipulate metabolic needs, and potentially lead to the development of interventions aimed at altering metabolism and lowering body temperature. In light of recent, rapid climate changes, a better understanding of the inherent behavioural and physiological means by which animals regulate temperature will also allow us to predict and assess more accurately how and if animals can successfully cope with these changes.

所有动物都需要氧气来维持有氧代谢，并最终生存。 尽管如此，也有外部或内部产生的情况下，氧气是有限的，称为缺氧。 动物具有许多适应性来应对这些类型的环境压力。 我的研究项目的目标是了解动物如何在高代谢率或高体温不可能或无法维持的情况下控制体温和代谢，例如在缺氧，体温过低，冬眠，麻木或睡眠期间。 目前，该控件在体内的位置尚不清楚。 细胞和组织似乎有调节代谢的内在机制，但神经系统作为控制中心的作用却鲜为人知。 动物王国中普遍存在这些降低代谢状态，这表明在整个进化过程中非常需要开发替代生理策略来应对恶劣的环境条件。 我采取比较和综合的方法，研究自然进化出应对缺氧的生理防御的动物。 我一直在开发一个研究项目，旨在研究动物如何利用温度来改变它们的代谢需求，因为众所周知，寒冷会减缓代谢过程。 事实证明，所有动物都喜欢较低的体温，并且在缺氧时表现出较低的新陈代谢。 这是如何在生理和行为上控制的，以及为什么所有动物都表现出这种反应，特别是当缺氧只发生在某些环境或生命时期时，尚不清楚。 了解这一过程将揭示动物如何改变和操纵代谢需求，并可能导致旨在改变代谢和降低体温的干预措施的发展。 鉴于最近快速的气候变化，更好地了解动物调节温度的内在行为和生理手段也将使我们能够更准确地预测和评估动物如何以及是否能够成功科普这些变化。