Interplay of S. pombe DNA double-strand break repair proteins in meiotic recombination and aneuploidy

粟酒裂殖酵母 DNA 双链断裂修复蛋白在减数分裂重组和非整倍性中的相互作用

• 批准号: 283095-2009
• 负责人: Masson, JeanYves
• 金额: $ 2.99万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525609
• 关键词: Interplay; S.; pombe; DNA; double

In most eukaryotic organisms, haploid gametes are produced from diploid parental cells by the process of meiosis. During meiosis, genetic variation is introduced by meiotic recombination where chromosomes from each parent recombine (known as inter-homolog recombination) leading to gametes with different genetic signatures. Defects in meiotic recombination can cause cells to have the wrong number of chromosomes (aneuploidy), resulting in abnormal or inviable progeny. So far, studies into the biochemistry and genetics of human meiotic recombination has been hampered by the unavailability of human tissues such as ovaries or testis. Moreover, there is no meiotic human cell line that can be used as a model for meiotic recombination.

在大多数真核生物中，单倍体配子是由二倍体亲本细胞通过减数分裂过程产生的。在减数分裂过程中，遗传变异是通过减数分裂重组引入的，其中来自每个亲本的染色体重组(称为同源重组)导致具有不同遗传特征的配子。减数分裂重组的缺陷可能会导致细胞的染色体数目错误(非整倍体)，导致不正常或无法存活的后代。到目前为止，由于无法获得卵巢或睾丸等人体组织，对人类减数分裂重组的生物化学和遗传学研究一直受到阻碍。此外，目前还没有减数分裂的人类细胞系可以作为减数分裂重组的模型。