Interplay of S. pombe DNA double-strand break repair proteins in meiotic recombination and aneuploidy

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In most eukaryotic organisms, haploid gametes are produced from diploid parental cells by the process of meiosis. During meiosis, genetic variation is introduced by meiotic recombination where chromosomes from each parent recombine (known as inter-homolog recombination) leading to gametes with different genetic signatures. Defects in meiotic recombination can cause cells to have the wrong number of chromosomes (aneuploidy), resulting in abnormal or inviable progeny. So far, studies into the biochemistry and genetics of human meiotic recombination has been hampered by the unavailability of human tissues such as ovaries or testis. Moreover, there is no meiotic human cell line that can be used as a model for meiotic recombination.