Associative learning in zebrafish
斑马鱼的联想学习
基本信息
- 批准号:311637-2011
- 负责人:
- 金额:$ 3.42万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2013
- 资助国家:加拿大
- 起止时间:2013-01-01 至 2014-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Although past research has explored the mechanisms of learning & memory, a lot remains to be discovered. I argue that the zebrafish will significantly accelerate the progress of this research. Zebrafish is a small freshwater fish. It is prolific, cheap to breed and keep in large numbers in the laboratory. It has several features typical of vertebrates and even similar to mammals, e.g., its genes are similar to human genes. Therefore, if one discovers a gene involved in learning & memory in zebrafish, it is likely that one will find the human gene homologous to it. Discovery of such genes may be faster with zebrafish because of the simplicity of this species. Indeed, large scale mutagenesis screens have been employed and led to the identification of genes affecting a range of biological processes from embryo development to cocaine addiction. However, such screens may only be performed if appropriate screening methods are available. Unfortunately, such methods are lacking for learning & memory in zebrafish. The goal of the proposal is to fill this gap. We will study whether zebrafish are capable of simple and complex forms of learning and memory typical of more advanced vertebrates, e.g. mammals. We will study non-spatial and spatial associative learning and other forms of complex learning where relationships of multiple cues must be acquired. For example, we will analyze how zebrafish learn that a visual cue predicts the appearance of a group of zebrafish (a reward), or of a dangerous predator (a punishment), or where in their test environment these stimuli will appear, or what other cues may influence when and where these stimuli appear. Also, we will investigate how long zebrafish may remember certain stimuli, and we will dissociate different memory processes and study short term, medium term and long term memory of this fish. We will develop software applications to allow computer controlled presentation of cues and automated quantification of behavioural responses. This way many learning tests can be run in parallel and thus a large number of fish can be tested. In the future, this will allow us and others to screen a large number of mutations and identify those that are involved in specific learning and memory processes.
虽然过去的研究已经探索了学习和记忆的机制,但仍有许多有待发现。我认为,斑马鱼将大大加快这项研究的进展。斑马鱼是一种小型淡水鱼。它的产量多,繁殖成本低,并在实验室中大量饲养。它具有脊椎动物的几个典型特征,甚至与哺乳动物相似,例如,它的基因和人类的基因相似。因此,如果在斑马鱼中发现了与学习和记忆有关的基因,很可能会发现与之同源的人类基因。由于斑马鱼的简单性,在斑马鱼中发现这样的基因可能会更快。事实上,已经采用了大规模诱变筛选,并导致鉴定影响从胚胎发育到可卡因成瘾的一系列生物过程的基因。但是,只有在有适当的筛选方法时才可进行此类筛选。不幸的是,这种方法在斑马鱼的学习和记忆中缺乏。该提案的目的是填补这一空白。我们将研究斑马鱼是否具有更高级脊椎动物(例如哺乳动物)典型的简单和复杂形式的学习和记忆能力。我们将研究非空间和空间联想学习和其他形式的复杂学习,其中必须获得多个线索的关系。例如,我们将分析斑马鱼如何学习视觉线索预测一群斑马鱼的出现(奖励),或危险的捕食者(惩罚),或者这些刺激将出现在测试环境中的什么地方,或者什么其他线索可能会影响这些刺激出现的时间和地点。此外,我们将调查多久斑马鱼可能记住某些刺激,我们将分离不同的记忆过程,并研究这种鱼的短期,中期和长期记忆。我们将开发软件应用程序,使计算机控制的提示和自动量化的行为反应。这样,许多学习测试可以并行运行,因此可以测试大量的鱼。在未来,这将使我们和其他人能够筛选大量的突变,并确定那些参与特定学习和记忆过程的突变。
项目成果
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Gerlai, Robert其他文献
Individual differences in activity levels in zebrafish (Danio rerio).
- DOI:
10.1016/j.bbr.2013.09.040 - 发表时间:
2013-11-15 - 期刊:
- 影响因子:2.7
- 作者:
Tran, Steven;Gerlai, Robert - 通讯作者:
Gerlai, Robert
Impairment of social behaviour persists two years after embryonic alcohol exposure in zebrafish: A model of fetal alcohol spectrum disorders
- DOI:
10.1016/j.bbr.2015.05.060 - 发表时间:
2015-10-01 - 期刊:
- 影响因子:2.7
- 作者:
Fernandes, Yohaan;Rampersad, Mindy;Gerlai, Robert - 通讯作者:
Gerlai, Robert
Alarm substance induced behavioral responses in zebrafish (Danio rerio)
- DOI:
10.1016/j.bbr.2007.10.031 - 发表时间:
2008-03-17 - 期刊:
- 影响因子:2.7
- 作者:
Speedie, Natasha;Gerlai, Robert - 通讯作者:
Gerlai, Robert
Effects of nicotine and alcohol on zebrafish (Danio rerio) shoaling
- DOI:
10.1016/j.bbr.2012.11.033 - 发表时间:
2013-03-01 - 期刊:
- 影响因子:2.7
- 作者:
Miller, Noam;Greene, Keisha;Gerlai, Robert - 通讯作者:
Gerlai, Robert
Can angelfish (Pterophyllum scalare) count? Discrimination between different shoal sizes follows Weber's law
- DOI:
10.1007/s10071-010-0337-6 - 发表时间:
2011-01-01 - 期刊:
- 影响因子:2.7
- 作者:
Gomez-Laplaza, Luis M.;Gerlai, Robert - 通讯作者:
Gerlai, Robert
Gerlai, Robert的其他文献
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{{ truncateString('Gerlai, Robert', 18)}}的其他基金
Associative Learning in Zebrafish
斑马鱼的联想学习
- 批准号:
RGPIN-2022-03076 - 财政年份:2022
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2021
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2020
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2019
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2018
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2017
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2016
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning in zebrafish
斑马鱼的联想学习
- 批准号:
311637-2011 - 财政年份:2015
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning in zebrafish
斑马鱼的联想学习
- 批准号:
311637-2011 - 财政年份:2014
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning in zebrafish
斑马鱼的联想学习
- 批准号:
311637-2011 - 财政年份:2012
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
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相似海外基金
Associative Learning in Zebrafish
斑马鱼的联想学习
- 批准号:
RGPIN-2022-03076 - 财政年份:2022
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
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RGPIN-2016-05604 - 财政年份:2021
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$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2020
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2019
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2018
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2017
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning and memory in zebrafish
斑马鱼的联想学习和记忆
- 批准号:
RGPIN-2016-05604 - 财政年份:2016
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning in zebrafish
斑马鱼的联想学习
- 批准号:
311637-2011 - 财政年份:2015
- 资助金额:
$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning in zebrafish
斑马鱼的联想学习
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$ 3.42万 - 项目类别:
Discovery Grants Program - Individual
Associative learning in zebrafish
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Discovery Grants Program - Individual