NCAM influences RGC numbers: mechanisms and implications for vision

NCAM 影响 RGC 数量：机制及其对视力的影响

• 批准号: 312303-2011
• 负责人: Clarke, David
• 金额: $ 2.19万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=526464
• 关键词: NCAM; influences; RGC; numbers; mechanisms

Our laboratory has been interested in exploring mechanisms that are relevant to the survival of central nervous system (CNS) neurons. Our recent studies, made possible by NSERC funding, have demonstrated that the neural cell adhesion molecule (NCAM) and its polysialylated form (PSA-NCAM) play roles in survival of young adult CNS neurons in the retina. NCAM is a cell surface protein and PSA is a carbohydrate localized almost exclusively on NCAM; both have been implicated in various functions of cellular development and regeneration. There is increasing evidence suggesting that NCAM plays an essential role in the adult nervous system; however, its influence on neuron survival and function in aging has not yet been described.

我们的实验室一直对探索与中枢神经系统(CNS)神经元生存相关的机制感兴趣。在NSERC的资助下，我们最近的研究表明，神经细胞黏附分子(NCAM)及其多唾液酸化形式(PSA-NCAM)在视网膜中年轻成年CNS神经元的存活中发挥作用。NCAM是一种细胞表面蛋白，PSA是一种几乎完全定位于NCAM的碳水化合物；两者都参与了细胞发育和再生的各种功能。越来越多的证据表明，NCAM在成人神经系统中发挥着重要的作用；然而，它对神经元在衰老过程中的存活和功能的影响尚未被描述。