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NCAM influences RGC numbers: mechanisms and implications for vision

NCAM influences RGC numbers: mechanisms and implications for vision
NCAM 影响 RGC 数量：机制及其对视力的影响
批准号：
312303-2011
负责人：
Clarke, David
金额：
$2.19万
依托单位：
Dalhousie University
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-01-01 至 2015-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548694
关键词：
NCAMinfluencesRGCnumbersmechanisms

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英文摘要
Our laboratory has been interested in exploring mechanisms that are relevant to the survival of central nervous system (CNS) neurons. Our recent studies, made possible by NSERC funding, have demonstrated that the neural cell adhesion molecule (NCAM) and its polysialylated form (PSA-NCAM) play roles in survival of young adult CNS neurons in the retina. NCAM is a cell surface protein and PSA is a carbohydrate localized almost exclusively on NCAM; both have been implicated in various functions of cellular development and regeneration. There is increasing evidence suggesting that NCAM plays an essential role in the adult nervous system; however, its influence on neuron survival and function in aging has not yet been described.
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