Metal-organic compounds as scaffolds and libraries, for the exploration of biologically relevant chemical space.

金属有机化合物作为支架和库，用于探索生物相关的化学空间。

• 批准号: 326972-2013
• 负责人: Luyt, Leonard
• 金额: $ 2.48万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=526763
• 关键词: Metal; organic; compounds; scaffolds; libraries

The ability to create ligands with affinity for a protein target depends upon the presentation of functionality in specific locations of three dimensional space. Metal-based ligands have typically not been utilized for receptor targeting, and yet metal complexes have unique abilities in terms of addressing chemical space due to their higher coordination number and increased structural diversity. In addition, metal-organic ligands can be designed with features that are particularly valuable for combinatorial library screening and may be created to have fluorescent properties.

为蛋白质靶标创造具有亲和力的配体的能力取决于三维空间中特定位置的功能的呈现。金属配体通常不被用于受体靶向，然而金属配合物由于其较高的配位数和增加的结构多样性而在寻址化学空间方面具有独特的能力。此外，金属-有机配体可以设计成具有对组合文库筛选特别有价值的特征，并且可以被创建为具有荧光特性。