Automated prediction of protein complex substructure from genomics and proteomics data

根据基因组学和蛋白质组学数据自动预测蛋白质复杂子结构

• 批准号: 341427-2010
• 负责人: Bader, Gary
• 金额: $ 1.97万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527302
• 关键词: Automated; prediction; protein; complex; substructure

Experimental determination of interactions among cellular components, including biochemical reactions, protein-protein and genetic interactions, charts a map of the cell. This map defines gene function and is the basis of our models of biological processes. This knowledge will eventually enable us to predict phenotype from genotype, understand the genetic basis of disease and engineer new biological systems for industrial applications.

实验测定细胞成分之间的相互作用，包括生化反应，蛋白质-蛋白质和遗传相互作用，绘制细胞图。该图谱定义了基因功能，是我们生物过程模型的基础。这些知识最终将使我们能够从基因型中预测表型，了解疾病的遗传基础，并为工业应用设计新的生物系统。